Carboxymethyl chitosan, its preparing method and usage
A technology of carboxymethyl chitosan and chitosan, which is applied in the field of carboxymethyl chitosan that can replace hyaluronic acid and its preparation, can solve the problems of small amount and high price, and achieve low cost and high production method The effect of simple, good moisturizing properties
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Embodiment 1
[0011] Embodiment 1: get 50g degree of deacetylation and be that the raw material chitosan of 0.9 is dissolved in the acetic acid solution of 10% (percentage by weight, hereinafter the same), fully stir after adding acetic anhydride, form gel after standing one night at room temperature or Clear solution. The gel was dehydrated with ethanol solution containing 0.5M KOH, and the solution was dehydrated with NH 4 OH precipitation, and then the product was repeatedly washed with 75% ethanol solution, and vacuum-dried to obtain N-acetylated chitosan. After N-acetylated chitosan was fully alkalized in 50% sodium hydroxide solution, 300 ml of isopropanol was added, and 80 g of chloroacetic acid was added, and reacted at 70° C. for 5 hours. After the end, the product was adjusted to neutrality with dilute hydrochloric acid to obtain carboxymethyl chitosan with a degree of substitution of 0.78 and a degree of deacetylation of 0.56. Its moisturizing properties are listed in Table 1. ...
Embodiment 2
[0012] Example 2: 50 g of chitosan with a degree of deacetylation of 0.85 was dissolved in 10% acetic acid solution, fully stirred after adding acetic anhydride, and left overnight at room temperature to form a gel or a clear solution. The gel was dehydrated with ethanol solution containing 0.8M NaOH, and the solution was dehydrated with NH 4 OH precipitation, and then the product was repeatedly washed with 70% ethanol solution, and vacuum-dried to obtain N-acetylated chitosan. After N-acetylated chitosan was fully alkalized in 60% sodium hydroxide solution, 300 ml of isopropanol was added, and 50 g of chloroacetic acid was added, and reacted at 70° C. for 5 hours. After the end, the product was adjusted to neutrality with dilute hydrochloric acid to obtain carboxymethyl chitosan with a degree of substitution of 0.63 and a degree of deacetylation of 0.40. Its moisturizing properties are listed in Table 1.
Embodiment 3
[0013] Embodiment 3: get 80g deacetylation degree and be that the raw material chitosan of 0.95 is dissolved in the acetic acid solution of 30%, fully stir after adding acetic anhydride, form gel or clear solution after standing; Gel uses the ethanol of 0.5M NaOH The solution was dehydrated, and the solution was dehydrated with NH 4 OH precipitation, then the product was washed repeatedly with 60% ethanol solution, and dried in vacuum to obtain N-acetylated chitosan; then N-acetylated chitosan was fully alkalized in 40% sodium hydroxide solution, and then added Add 500ml of isopropanol, then add 100g of chloroacetic acid, and react at 40-70°C for 5-8 hours; after the end, the product is adjusted to neutrality with dilute hydrochloric acid to obtain carboxymethyl chitosan with a degree of substitution of 0.60 and a degree of deacetylation of 0.65 . Its moisturizing properties are listed in Table 1.
[0014] Example 1
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