Improvements in blood filters, blood collection and processing system and methods therefor

A blood processing and filter technology, applied in the field of blood collection and processing filters, can solve the problems of complex manufacturing process, increased loss of raw materials, waste of raw materials, etc.

Inactive Publication Date: 2003-08-06
BAXTER INT INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although filter media consisting of non-woven fibers or porous materials wrapped in a hard shell (such as polycarbonate) have been widely used in traditional leukocyte removal filters, there is a problem: that is, due to the poor gas permeability of the shell, Or practically impermeable at all, the steam sterilization operation widely used to sterilize blood separation devices is difficult to apply to the above filters
[0010] However, in the above-mentioned leukocyte-removing filter, the filter member should be fused to the elastic structural sheet at one time, and then the structure is fused to the housing material, causing a problem that the manufacturing process becomes complicated
And there is another problem: most of the raw material is wasted by penetrating the sheets in the structure to ensure effective filtration channels
As a result, there is the same risk of damage as with previous filter units with a rigid plastic housing: damage to the channel itself due to the pressure generated during centrifugation
The filter in the previous patent application JP7-267871 also has some disadvantages: because the outermost peripheral edge of the filter element is welded to the shell material, when the welded part is damaged due to mishandling and violent handling during the filtration process or due to centrifugal pressure Risk of infection of medical workers or bacterial contamination of blood preparations cannot be avoided in the event of a rupture resulting in a leak
[0013] The object of the present invention is to provide a kind of elastic blood treatment filter without using lamellar elastic structure, which eliminates the above-mentioned defects of complicated manufacturing process and increased loss of raw materials

Method used

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  • Improvements in blood filters, blood collection and processing system and methods therefor
  • Improvements in blood filters, blood collection and processing system and methods therefor
  • Improvements in blood filters, blood collection and processing system and methods therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] The elastic polyvinyl chloride resin membranes b and d are cut to the size of the blood filter plus 20mm, and holes are provided on it at positions corresponding to the blood inlet a and the blood outlet e, which are made of polyvinyl chloride resin and formed by injection molding, and the resin films b and d are connected to each other by high frequency welding, thereby manufacturing an elastic case b provided with a blood inlet a and an elastic case d provided with a blood outlet e.

[0111] Polyester nonwoven fibers as described below were laminated to form a filter member c. Laminate the following materials in the following order: four layers of non-woven fiber 1 as the first filter element, its average fiber size is 12-15 μm, and the fiber density is 29-31g / m 2 ;A total of 27 layers of non-woven fibers are used as the second filter element, which includes-having an average fiber size of 1.5-2.0 μm and a fiber density of 65-67g / m 2 A layer of nonwoven fibers 2 havi...

Embodiment 2

[0117] Cut the filter part c into a size of 82mm x 65mm. The first closed area was welded so that the width of the protruding filter member g was 0.5 mm.

[0118] After performing the leak detection of the first closed portion, a filter was produced in the same manner as in Example 1, except that the elastic shells b and d were welded to form a non-closed region h with a width of 1 mm. The results of the leak test performed by the above method are shown in Table 1.

Embodiment 3

[0120] Example 1 was carried out except that the filter member was cut to a size of 87×70 mm so that the width of the protruding part (g) was 3 mm and the width of the non-enclosed area (h) was 6 mm. The difference between the maximum width and the minimum width of the protruding filter member was 1 mm. The results of the leak test before and after sterilization / centrifugation are shown in Table 3.

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Abstract

A blood collection system has a container for holding blood and a filter communicating with the container, mutually arranged for handling as a unit. The filter (20) contains a fibrous filter medium (28) housed within two flexible sheets (32, 34) of plastic. A first seal (36) joins the sheets (32, 34) directly to the filter medium (28) inboard of the peripheral edge (40) of the filter medium (28), and a second seal (38) joins the sheets (32, 34) outboard of the peripheral edge (40) of the filter medium (28). A region (42) of the filter medium (28) extends between the first and second seals (36, 38) to cushion contact with the filter housing during handling.

Description

technical field [0001] The present invention relates generally to blood collection and processing filters, systems and methods for reducing the presence or removing unwanted constituents, such as clots and white blood cells (leukocytes), from blood. More particularly, the present invention relates to precision disposable blood processing filters and systems incorporating the same for the removal of microscopic agglutinates and white blood cells from whole blood preparations for transfusion, red blood cell preparations, platelet preparations and plasma preparations . The invention further relates to a blood processing filter which is optimally adapted to undergo centrifugation for the separation of each blood component, wherein the filter itself is centrifuged together with the blood holding bag and other components of the blood filtration system. Background technique [0002] Systems consisting of multiple interconnected plastic bags are widely used and accepted for collect...

Claims

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Application Information

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IPC IPC(8): A61M1/02A61M1/36
CPCA61M2202/0439A61M2001/3636A61M2001/0218A61M2205/7545A61M1/3633A61M1/0218A61M1/3636A61M1/0227A61J1/05
Inventor 丹尼尔·R·林恩艾伦·R·翁斯卢茨·梅斯普弗丹尼尔·范登道尔格雷戈里·苏当塔特·C·穆伊丹尼尔·M·卡尔洛夫斯基兰迪·墨菲丹尼尔·R·卡尔霍恩冈慎一郎辻道弘
Owner BAXTER INT INC
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