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Insoluble medicine tablet and preparing process thereof

A technology for insoluble drugs and tablets, which is used in pharmaceutical formulations, pill delivery, medical preparations with inactive ingredients, etc. The surface is smooth and beautiful, and the effect of high hardness

Inactive Publication Date: 2003-10-29
YANGTZE RIVER PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides a method that solves the problem that insoluble drugs are difficult to compress into tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1 Preparation of Iguratimod tablets.

[0010] The specification is 50 mg / tablet, and the proportioning ratio for pressing into 1000 tablets is: iguratimod 50g, lactose 70g, PH10160g, carboxymethyl starch sodium 9g, 10% povidone K30 solution and 1g magnesium stearate. The preparation process is to dry the raw and auxiliary materials respectively below 80 DEG C, so that the water content is controlled within 3%. Take the prescribed amount of Alamod raw materials, add the prescribed amount of lactose, mix and grind them thoroughly, pass through an 80-mesh sieve, add the prescribed amount of PH101 and sodium starch glycolate that have been dried and passed through a 100-mesh sieve, mix well, and use 10% povidone Soft material made from K30 solution, granulated with a 24-mesh sieve, the granules were dried with hot air below 80°C, and the water content was controlled within 3%. The weight of the tablet is pressed, and the product is obtained. The product is tested ...

Embodiment 2

[0012] Example 2 Preparation of bambuterol hydrochloride tablets.

[0013] The specification is 10mg / tablet, and the proportioning ratio for pressing into 1000 tablets is: 10g of bambuterol hydrochloride, 50g of lactose, 40g of PH103, 10g of sodium starch glycolate, an appropriate amount of 10% povidone solution and 1g of magnesium stearate. The preparation process is to dry the raw and auxiliary materials at 60°C, weigh the raw material of bambuterol hydrochloride in the prescribed amount, add the lactose in the prescribed amount, mix and pulverize them thoroughly, pass through a 100-mesh sieve, add the PH103 and sodium starch glycolate in the prescribed amount, and mix Uniformly, use 10% povidone K30 solution to make soft materials, granulate with 24 mesh sieves, dry the wet granules with hot air at 60°C, control the moisture content within 3%, add the prescribed amount of magnesium stearate, mix evenly, and prepare granules, detect the content of intermediates, calculate th...

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PUM

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Abstract

A tablet of the insoluble medicine is prepared through mixing said medicine with lactose, pulverizing, sieving, mixing with microcrystal cellulose powder and carboxymethyl starch sodium, preparing soft material with povidone K30 solution, granulating, drying at 50-80 deg.C, mixing with lubricant, and tabletting. Its advantage is high solubility of medicine (more than 90%).

Description

Technical field [0001] The invention relates to an insoluble drug tablet and a preparation method thereof. Background technique [0002] Generally, insoluble and flocculent drugs are very loose. Due to the strong electrostatic effect when crushed separately, they quickly gather into agglomerates after crushing, so it is difficult to pass through a sieve of 40 mesh or more, so that they cannot be mixed evenly with excipients. , resulting in uneven content of the compressed tablet. Contents of the invention [0003] The invention provides a method for solving the problem that insoluble drugs are difficult to be compressed into tablets. [0004] The technical scheme of the present invention is: the main weight composition of its medicine is: lactose 20%--60%, microcrystalline cellulose 20%--50%, carboxymethyl starch sodium 5%--20%, lubricant 0.3%-- -1.0%. [0005] The present invention preferably adopts microcrystalline cellulose of PH101 or PH103 type, magnesium stearate ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38
Inventor 张正艮李旭东王进义王林孙海胜
Owner YANGTZE RIVER PHARM GRP CO LTD
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