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Oral medicine of leucovocin calcium and its preparing method

A technology of calcium levofolinate and medicaments, which is applied in the direction of medical formulas, medical preparations containing active ingredients, pill delivery, etc., can solve problems such as difficulty in popularizing and applying in large quantities, high cost of preparation, and single variety of medicaments. The effects of widely popularizing and applying, reducing production costs and improving work efficiency

Inactive Publication Date: 2003-11-19
杭州新望族科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, because the preparation process of the medicament is not perfect, the production method is complicated, and the selection of auxiliary materials is unreasonable, the preparation cost of this medicament is higher, the therapeutic effect of the prepared medicament is not ideal, and the variety of the medicament is relatively single, which is difficult to obtain. Mass promotion and application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0028] The prescription of example 1 preparation

[0029] Tablets containing calcium levofolinate as an active ingredient also have the following composition (prescription amount per 1,000 tablets): (a) 7.5 g calcium levofolinate, 6 g hypromellose, 8 g sodium starch glycolate, microcrystalline cellulose 8g, lactose 112g, starch 50g, magnesium stearate 1g. (b) Leucovorin calcium 5g, the rest is the same as (a). (c) 2.5 g of calcium levofolinate, and the rest are the same as (a).

example 2

[0030] Example 2 tablet preparation process

[0031] Weigh the main drug and auxiliary materials, crush the main drug and auxiliary materials separately, pass the main drug through a 120-mesh sieve, and pass the various auxiliary materials through a 100-mesh sieve respectively, fully mix the main drug and auxiliary materials and put them into a high-speed mixer, spray with appropriate amount of water, and granulate , the water content is controlled at 3-4%, and then pressed into tablets and coated with film.

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PUM

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Abstract

An orally applied calcium levo-pteroyglutamite in the form of tablet or particles for treating anemia and tumor is prepared from calcium levo-pteroyglutamite, filler, disintegrant, lubricant, adhesive, flowing aid and at least one additive through proportional mixing, tabletting or granulating, and coating. Its advantages are high curative effect and low cost.

Description

technical field [0001] The invention relates to an oral medicament with calcium levofolinate as the main active ingredient and a preparation method thereof, which is mainly used for anti-anemia and as a detoxification antagonist in drug treatment of tumors and the like. Background technique [0002] Calcium levofolinate is also known as (6S)--the medicinal value of calcium folinate has been paid more and more attention by people, especially for the treatment of anemia and antidote antagonists in tumor drug therapy. Therefore, many medicines and related pharmaceutical technologies made of various medicaments with calcium levofolinate as active ingredients have been disclosed in relevant medical journals. But at present, because the preparation process of the medicament is not perfect, the production method is complicated, and the selection of auxiliary materials is unreasonable, the preparation cost of this medicament is higher, the therapeutic effect of the prepared medicame...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/48A61K9/52A61K31/519A61P7/06A61P35/00
Inventor 姚培元黄羿
Owner 杭州新望族科技有限公司