Self-emulsifying agglomerant of oral polypeptide medicine

Abstract

An oral-applied self-emulsifying polypeptide medicine is prepared from polypeptide, gel adhesive, surfactant, co-surfactant, oil enzyme inhibitor, and diluent. Its preparing process is also disclosed. It features that after it comes in intestinal tract, it is emulsified by itself to become nano-class microemulsion, which can penetrate through intestinal mucosa and epithelial barrier into lymph and blood, and be attached on intestinal inner surface to promote its absorption.

Description

technical field [0001] The invention relates to an oral polypeptide drug preparation and a preparation method thereof. Background technique [0002] With the development of biotechnology and genetic engineering, more and more polypeptide and protein drugs are used in clinical treatment, and most polypeptide drugs are biologically active and unstable to heat and enzymes, so they are often given by injection. medicine. However, long-term injection administration brings great pain to patients, and requires special injection techniques, which makes it difficult for patients to administer medicines independently, resulting in high finished products and high medical expenses. Therefore, domestic and foreign pharmaceutical workers have been committed to the research of non-injection routes of polypeptide drugs, such as nasal cavity, rectal, oral, lung, eye, transdermal absorption and so on. Among the above-mentioned routes of administration, oral administration is particularly at...

AI Technical Summary

Problems solved by technology

There are many studies on the oral administration of polypeptide drugs such as INS, including liposomes, emulsions, enteric-coated preparations, etc., but the bioavailability has not exceeded 5%. In recent years, some new drug delivery systems have been used for oral administration of INS , such as nanoparticles (capsules), microemulsions, colon-targeted drug delivery systems, etc., but the results are still unsatisfactory

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