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Use of recombined human granulocyte colony stimulating factor in preparation of medicine for myocardiac infarction

A technology of colony stimulating factor and myocardial infarction, which is applied in the fields of drug combination, pharmaceutical formulation, cardiovascular system diseases, etc., can solve the problems of not being able to apply clinically quickly, a lot of manpower, and a long period of time, so as to shorten the need for preclinical research. Time, method is simple, the effect of saving a lot of investment

Inactive Publication Date: 2004-02-04
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the development of new drugs requires a lot of manpower, material and financial resources, and it takes a long time from its research and development, production to subsequent preclinical and clinical trials, so it cannot be quickly applied to clinical trials.

Method used

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  • Use of recombined human granulocyte colony stimulating factor in preparation of medicine for myocardiac infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A male patient with myocardial infarction was diagnosed by conventional electrocardiogram and myocardial enzyme examination, and then received subcutaneous injection of recombinant human granulocyte colony-stimulating factor 300 μg, once a day, for a total of 4 treatments. After the course of treatment, a single electron emission computer could be used. Tomography (SPECT) myocardial perfusion imaging examination, myocardial infarction area accounted for 33% of the total area of ​​ventricular muscle from before treatment (see figure 1 The black part of A) is reduced to 7% (see figure 1 the black portion of B).

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Abstract

An application of recombinant human granulocyte colony stimulating factor in preparing medicine for treating myocardial infaction is disclosed. Its advantages are high curative effect and safety, and low cost.

Description

technical field [0001] The invention relates to the application of recombinant human granulocyte colony-stimulating factor in the preparation of medicine for treating myocardial infarction. technical background [0002] Myocardial infarction is a common heart disease that seriously endangers human health in today's society. Human cardiomyocytes are terminally differentiated cells without the ability to divide and proliferate. Currently, conventional treatments for myocardial infarction, including drug therapy, interventional therapy, and surgical treatment, can only improve the blood perfusion of the remaining myocardium after myocardial infarction and avoid myocardial infarction. The foci further expanded, but the infarcted myocardial tissue could not be repaired. After conventional treatment, patients with myocardial infarction often lose the ability to work or even die of heart failure due to the decrease in the number of remaining myocardium and the decline in cardiac f...

Claims

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Application Information

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IPC IPC(8): A61K38/22A61P9/10
Inventor 陈运贤欧瑞明钟雪云钟立业
Owner SUN YAT SEN UNIV
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