Method for preparing biomedical amorphous nano calcium phosphate

A technology of amorphous calcium phosphate and nano-calcium phosphate, applied in chemical instruments and methods, medical science, phosphorus compounds, etc., can solve the problems of high price, complicated process, and non-adjustable amorphous calcium phosphate Ca/P ratio, etc., to achieve The effect of low cost, simple preparation process conditions and uniform particle distribution

Inactive Publication Date: 2004-04-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, to obtain impurity-free amorphous calcium phosphate can only be obtained by physical methods such as high-temperature melting of crystalline calcium

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0020] Example 1

[0021] Put Na 3 PO 4 ·12H 2 O was dissolved in 100ml of distilled water and stirred to form a solution A with a phosphorus concentration of 0.173M; CaCl 2 Dissolve in 200ml of distilled water to form a B solution with a calcium concentration of 0.130M. Add an appropriate amount of PEG (PEG: CaCl 2 =3:1, molar ratio, the polymer is calculated based on the number of moles of structural units, the same below) After dissolution, solution C is formed, and solutions A and C are stored at 5°C for refrigeration. After the temperature stabilizes at 5°C, the A solution is added dropwise to the C solution at a rate of 2ml / min, the pH is adjusted to maintain 10 with ammonia, and the reaction is carried out under magnetic stirring for 30 minutes, and the Ca / P ratio is 1.50. The precipitate was filtered, washed, and freeze-dried for 48 hours to obtain amorphous calcium phosphate, which was taken out and placed in a desiccator for storage.

Example Embodiment

[0022] Example 2

[0023] Put Na 3 PO 4 ·12H 2 O was dissolved in 100ml of distilled water and stirred to form a solution A with a phosphorus concentration of 0.173M; CaCl 2 Dissolve in 200ml of distilled water to form a B solution with a calcium concentration of 0.130M. Add an appropriate amount of PVA (PVA: CaCl 2 =3:1, molar ratio, the polymer is calculated based on the number of moles of structural units, the same below) After dissolution, solution C is formed, and solutions A and C are stored at 5°C for refrigeration. After the temperature stabilizes at 5°C, the A solution is added dropwise to the C solution at a rate of 2ml / min, the pH is adjusted to maintain 10 with ammonia, and the reaction is carried out under magnetic stirring for 30 minutes, and the Ca / P ratio is 1.50. The precipitate is centrifuged, washed, and spray dried to obtain amorphous calcium phosphate, which is taken out and placed in a desiccator for storage.

Example Embodiment

[0024] Example 3

[0025] Put Na 3 PO 4 ·12H 2 O was dissolved in 100ml of distilled water and stirred to form a solution A with a phosphorus concentration of 0.162M; the CaCl 2 Dissolve in 200ml of distilled water to form a B solution with a calcium concentration of 0.130M. Add an appropriate amount of PAA (PAA: CaCl 2 =3:1, molar ratio, the polymer is calculated based on the number of moles of structural units, the same below) After dissolution, solution C is formed, and solutions A and C are stored at 5°C for refrigeration. After the temperature stabilizes at 5°C, the A solution is added dropwise to the C solution at a rate of 2ml / min, the pH is adjusted to maintain 10 with ammonia water, and the reaction is carried out under magnetic stirring for 30 minutes, and the Ca / P ratio is 1.60. The precipitate was filtered, washed, and freeze-dried for 48 hours to obtain amorphous calcium phosphate, which was taken out and placed in a desiccator for storage.

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Abstract

The invention discloses a manufacturing method for amorphous nano calcium phosphate in medical field. The method uses phosphor-contained compound and calcium-contained compound as raw materials, uses polymer as stabilizer, carries on reaction under 0í½20íµ in water solution and produces into amorphous calcium phosphate.

Description

technical field [0001] The invention relates to a preparation method used as a biological bone substitute material, in particular to a preparation method of amorphous calcium phosphate with adjustable bioactivity and biodegradation rate. Background technique [0002] Calcium phosphate materials are widely used as bone replacement materials due to their similar chemical composition to the inorganic phase in bone. Because of its better bioactivity and biodegradability than crystalline calcium phosphate, amorphous calcium phosphate is widely used in biomedical fields such as biocoating and bone cement, and has attracted more and more attention from researchers. Amorphous calcium phosphate is an intermediate product in the preparation of hydroxyapatite in aqueous solution, which can be easily converted into crystalline calcium phosphate. For a long time, researchers have tried to find a way to obtain amorphous calcium phosphate in aqueous solution mor...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/12C01B25/32
Inventor 翁文剑李延报韩高荣杜丕一程逵沈鸽赵高凌张溪文
Owner ZHEJIANG UNIV
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