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New method for extracting cephalotaxine and percephalotaxine

A technology for homoharringtonine and harringtonine, which is applied in the field of extraction of biological components, can solve the problems of incapable of realizing continuous industrialized operation, destroying rare tree species resources, unfavorably protecting the ecological environment, and the like, so as to protect natural resources and ecological environment. The effect of environment, protection of species resources, and avoidance of solute chromatographic peak tailing

Inactive Publication Date: 2004-05-05
FUJIAN COSUNTER PHARMA
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  • Abstract
  • Description
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Problems solved by technology

[0004] The shortcomings of the above method are: complex production process, long cycle, poor operability, extremely small production volume, serious environmental pollution, low recovery rate, unable to realize industrialized continuous operation, and greatly destroy rare tree species resources, which is not conducive to protection ecosystem
[0006] This method has a large investment cost and still needs to use natural harringtonine as a raw material, which also has the disadvantages of the aforementioned traditional process

Method used

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  • New method for extracting cephalotaxine and percephalotaxine
  • New method for extracting cephalotaxine and percephalotaxine

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Embodiment Construction

[0022] The best embodiment of the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0023] The raw materials are first crushed into coarse powder with a crusher, and the powder particle size is 0.5-3mm. After the powdery material is alkalized with 10% dilute ammonia water, it is loaded into a 1000-liter material basket with a bulk density of 228kg / m 3 .

[0024] Hang the material basket with the material into the extraction kettle, close and lock the hoop, and put the liquid CO with 85% ethanol as entrainer 2 , after being heated by the preheater, it is put into the extraction kettle, and the material is subjected to forward supercritical extraction, CO 2 The flow rate is 180-190kg / h, the extraction time is 3h, the extraction temperature is 40°C, and the extraction pressure is 20Mpa; the supercritical fluid carrying the active ingredient is decompressed and cooled by the shut-off valve, and then enters the separator ...

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Abstract

A process for extracting the harringtonine and homoharringtonine from the small twigs and leaves of fortune plumyew through pulverizing, alkalizing with diluted ammonia water, supercritical Co2 fluid extracting, separating common cephalotaxus alkaloid, chromatography, recovering the harringtonine mixture, and respectively recrystallizing.

Description

technical field [0001] The invention relates to a method for extracting biological components, in particular to a method for extracting natural anticancer drugs-harringtonine and homotricetine. Background technique [0002] With the continuous development of science and technology, people have found treatments for many diseases that were originally incurable. An extremely rare tree species - Cephalotaxus Lanceolata K.M.Feng, clinically determined that the alkaloids contained in its bark and other parts - harringtonine and homoharringtonine are natural The advent of the anti-leukemia medicine, this kind of biological agent, has brought hope of life to many leukemia patients on the verge of death. [0003] The traditional extraction process is to use the bark of the three-pointed fir as raw material, use alcohol percolation, recover alcohol, undergo repeated acid-base treatment, chloroform extraction, and then undergo neutral alumina adsorption column chr...

Claims

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Application Information

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IPC IPC(8): C07D491/147
CPCY02P20/54
Inventor 李国平吴雪平
Owner FUJIAN COSUNTER PHARMA
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