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Rareearth beteropoly acid salt (blue) group anti-AIDS medicine and preparation process thereof

A heteropoly acid salt and anti-AIDS technology, which is applied in the field of rare earth heteropoly acid salt compounds to achieve the effects of low price, strong virus replication and strong acid-base stability

Inactive Publication Date: 2004-06-09
NORTHEAST NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, none of the existing reports contain the general formula A x (H 2 O) x [A y ln z (H 2 O) 2x Cl q x j Ti m m a 12-m o 40 ]·nOg(I) compound as an active ingredient in the anti-AIDS in monkeys reported

Method used

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  • Rareearth beteropoly acid salt (blue) group anti-AIDS medicine and preparation process thereof
  • Rareearth beteropoly acid salt (blue) group anti-AIDS medicine and preparation process thereof
  • Rareearth beteropoly acid salt (blue) group anti-AIDS medicine and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Embodiment 1: the preparation of HPB-1

[0092] Sodium tungstate dihydrate (600 grams, 1.82mol), sodium dihydrogen phosphate (120 grams, 0.86mol) were dissolved in 2000 grams of distilled water, titanium tetrachloride (61 grams, 0.32mol) was added dropwise, back distillation 20 minutes, After filtration, 600 g of solid KCl was added to the filtrate to obtain a white precipitate. The precipitate was recrystallized with 500 g of hot water to give solid K 7 PTi 2 W 10 o 40 ·5H 2 O66g, K 7 PTi 2 W 10 o 40 ·5H 2 Dissolve O66g in 500g of water, add 11g of hydroxylamine hydrochloride and stir, then add 11g of lanthanum chloride, stir at 40-80°C for 2-8 hours, a few days later a colorless crystal K will precipitate 4 (H 2 O) 4 [K 3.5 La 0.5 (H 2 O) 8 ClPTi 2 W 10 o 40 ]·NH 2 Oh. The molecular structure diagram is attached figure 1 . The HPB-1 production flow chart is attached figure 2 .

Embodiment 2

[0093] Embodiment 2: the preparation of HPB-2

[0094] Prepare K by the method of above-mentioned embodiment 1 7 PTi 2 W 10 o 40 ·5H 2 O, K 7 PTi 2 W 10 o 40 ·5H 2 Dissolve O66 g in 500 g of water, add 9 g of hydrazine hydrate and stir, then add 12 g of neodymium chloride, and stir at 40-80°C for 2-8 hours. After a few days, purple crystals of K were precipitated 4 (H 2 O) 4 [K 3.5 Nd 0.5 (H 2 O) 8 ClPTi 2 W 10 o 40 ]·NH 2 NH 2 (HPB-2) 80g.

[0095] The preparation method of the above examples 1 and 2 can be arbitrarily enlarged or reduced according to the mass ratio of the formula.

[0096] The synthesized HPB-1, HPB-2 and excipients can be made into capsules at a weight ratio of 1:3. According to the ratio of its weight to the excipient of 1:3, it is made into a compressed tablet. Add water for injection according to the conventional injection preparation method, filter, potting and sterilize to make injection.

Description of drawings

[0097] atta...

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Abstract

The present invention belongs to the field of chemical synthetic medicine, and provides a kind of rare-earth heteropolyacid salt (blue) medicine for resisting AIDS. Said ivnention provides its general formula. Said medicine is low in toxic side effect, and has the strong action for inhibiting virus replication for HIV infected cell and SIV (acute simian immunodeficiency virus).

Description

technical field [0001] The invention belongs to the field of chemical synthesis medicine, and relates to rare earth heteropolyacid salt (blue) compounds. Background technique [0002] Since the first AIDS case was discovered in the 1980s, AIDS has spread rapidly around the world. At present, there are about 60 million HIV / AIDS patients in the world, and about 16,000 new infections every day. This disease is an infectious disease characterized by human immunodeficiency. AIDS reproduces in a large number of cells through HIV, destroys CD4 cells, and reduces and loses the immune ability of cells. Nucleoside drugs (AZT) and protease inhibitors approved by the U.S. FDA, used alone or in combination, can inhibit virus replication, partially restore the body's immune level, and delay the patient's life, but these drugs are expensive and prone to Drug resistance, high toxicity and side effects. [0003] The medicinal chemistry research of heteropoly compounds has been reported sin...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61P31/18
Inventor 王恩波李泽琳韩正波曾毅刘术侠
Owner NORTHEAST NORMAL UNIVERSITY
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