Water-soluble propolis and its extraction method

A technology of water-soluble propolis and its extraction method, which is applied in the fields of health care products, propolis and its extraction, cosmetics and food additives, water-soluble propolis and its water extraction, and can solve the problem of biological activity and human body absorption rate being inferior to that of water-extracted ideal product formulations Restriction, not suitable for taking and other issues, to achieve the effect of being easily absorbed by the body, reducing alcohol allergy, and reducing allergen ingredients

Inactive Publication Date: 2004-07-28
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product has a strong smell and strong irritation, which is difficult for most consumers to accept and is not suitable for consumption
Alcohol-extracted propolis solid dosage form products are not very irritating, but the dosage form of the product is limited, and its biological activity and human absorption rate are not as ideal as those of water-extracted propolis.

Method used

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  • Water-soluble propolis and its extraction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 An example of the method of the present invention

[0018] Take propolis raw material (hair glue), use water as a solvent, add 1% lecithin, the solution is ultrasonically treated for 15-45 minutes, the temperature is controlled at 60-80°C, and the heating time is 10-16 hours, extracted and filtered to obtain propolis water extraction. liquid.

[0019] See accompanying drawing 1 for the simple technological process.

[0020] By adopting the method of the invention, the propolis extract with a total flavonoid content as high as 12.765 mg / ml can be extracted. However, the content of flavonoids in propolis water extract obtained by conventional cold water extraction is only 1.914mg / ml. Although the total flavonoid content of propolis alcohol extract is up to 51.36mg / ml under corresponding conditions, when dissolved in water, 100ml of water can only dissolve 4-6ml of propolis alcohol extract. The extraction rate of flavonoids in water-soluble propolis is much...

Embodiment 2

[0021] Example 2 The anti-inflammatory immune effect of water-extracted propolis liquid

[0022] Four animal models of acute inflammation were used (rat paw swelling model induced by carrageenan, mouse abdominal capillary permeability increase model induced by acetic acid, rat pleurisy model induced by carrageenan, and acute rat model induced by oleic acid plus LPS). Lung injury model) and mouse cotton ball granuloma chronic inflammation model, complete Freund's adjuvant-induced immune inflammation model in rats, a total of 6 batches of whole animal experiments have observed the anti-inflammatory effect of propolis water extract, on this basis from The anti-inflammatory effect and mechanism of the propolis water extract extracted by this method were studied in many aspects and levels, such as the generation and release of inflammatory mediators, lipid peroxide content and SOD activity, cytokines, adhesion molecules, and transcriptional regulators. Studies have shown that the e...

Embodiment 3

[0023] Example 3 The effect of water-extracted propolis liquid on diabetes

[0024] The propolis liquid extracted by the method of the invention has a good preventive effect on diabetes under the condition of restricted feeding, and the effect is better than that of the propolis alcohol extract of the same dose. Propolis water extract can reduce the blood sugar level in diabetic rats: after 2 weeks of administration, compared with the model group, the blood sugar of the water extract group decreased by 22.3% (P<0.05), while that of the alcohol extract group decreased by 12.8%; Compared with the model group, the water extract group decreased by 22.2% (P<0.01), while the alcohol extract group decreased by 15.2% (P<0.01); after 4 weeks of administration, compared with the model group, the water extract group decreased 17.9% (P<0.05), while the alcohol extract group decreased by 6.8%; after 5 weeks of administration, the water extract group decreased by 27.3% (P<0.01), while the a...

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Abstract

The present invention provides a water-soluble propolis and its extraction method. The method utilizes the solubilization, ultrasonic technique and control of reasonable temp. and heating time to extract the active component in the propolis. The method does not utilize alcohol, and the total flavone content of propolis liquor extracted by said method can be up to 12.765 mg / ml. It has the good action of resisting inflammation, raising immunity, reducing blood sugar and preventing diabetic complicating disease. The invention can be extensively used in food, cosmetics and food additive.

Description

technical field [0001] The invention belongs to the field of deep processing of bee products, and relates to a propolis and an extraction method, in particular to water-soluble propolis and a water extraction method. The propolis raw material prepared by the invention is especially suitable for health care products, cosmetics and food additives. Background technique [0002] At present, the active ingredients of propolis products at home and abroad are basically obtained through alcohol extraction. The traditional propolis alcohol extraction method has an unacceptable irritating taste, and people who are allergic to alcohol are prone to allergic reactions when used, which increases allergens. It is very restrictive as a raw material for cosmetics and oral health products, and propolis alcohol extraction The liquid is not easily soluble in water, the absorption and utilization rate is low, and some of the water-soluble active ingredients have not been extracted. Other extrac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L21/20
Inventor 胡福良李英华王超敏
Owner ZHEJIANG UNIV
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