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Ixeris sonchifolia pharmaceutical formulation and its preparation method

A technology for pharmaceutical preparations and Kudiezi, which is applied in the field of Kudiezi pharmaceutical preparations and its preparation, can solve problems such as unseen products on the market, and achieve the effects of controllable drug quality, convenient storage and transportation, and reasonable process.

Inactive Publication Date: 2004-09-01
崔彬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there are only a few manufacturers in China producing Kudiezi injection, and there are also literature reports on Kudiezi freeze-dried powder injection, but no such products are listed on the market at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add 10 kg of Kudiezi to the multi-functional extraction tank, add 35 times the amount of water, decoct for 4 hours, extract the active ingredients to 0.6 grams of the original drug per ml, cool the concentrated solution to 18°C, adjust the pH to 10, filter Take the precipitate, weigh it, add ethanol in an amount 5.8 times the weight of the precipitate, adjust the pH to 4 with hydrochloric acid, filter, adjust the pH of the filtrate to 8 with NaOH solution, and collect the precipitate by filtration. Add the precipitate to water for injection to equal to 3.8 grams of crude drug per ml, refrigerate at -5°C for 12 hours, add 0.2% activated carbon to the filtrate, boil for 20 minutes, then put it at -5°C for 30 hours, filter, and adjust the pH To 7, filter with a vertical melting funnel and a microporous membrane (0.65 μm) respectively to obtain the active ingredient extract of Kudiezi.

[0019] The above-mentioned extract is dried to obtain Kudiezi extract powder, and Kudie...

Embodiment 2

[0021] Add 10 kg of Kudiezi to the multi-functional extraction tank, add 35 times the amount of water, decoct for 4 hours, extract the active ingredients to 0.6 grams of the original drug per ml, cool the concentrated solution to 18°C, adjust the pH to 10, filter Take the precipitate, weigh it, add ethanol in an amount 5.8 times the weight of the precipitate, adjust the pH to 4 with hydrochloric acid, filter, adjust the pH of the filtrate to 8 with NaOH solution, and collect the precipitate by filtration. Add the precipitate to water for injection to equal to 3.8 grams of crude drug per ml, refrigerate at -5°C for 12 hours, add 0.2% activated carbon to the filtrate, boil for 20 minutes, then put it at -5°C for 30 hours, filter, and adjust the pH To 7, filter with a vertical melting funnel and a microporous membrane (0.65 μm) respectively to obtain the active ingredient extract of Kudiezi.

[0022] The above-mentioned extract is dried to obtain Kudiezi powder, and Kudiezi capsu...

Embodiment 3

[0024] Add 10 kg of Kudiezi to the multi-functional extraction tank, add 35 times the amount of water, decoct for 4 hours, extract the active ingredients to 0.6 grams of the original drug per ml, cool the concentrated solution to 18°C, adjust the pH to 10, filter Take the precipitate, weigh it, add ethanol in an amount 5.8 times the weight of the precipitate, adjust the pH to 4 with hydrochloric acid, filter, adjust the pH of the filtrate to 8 with NaOH solution, and collect the precipitate by filtration. Add the precipitate to water for injection to equal to 3.8 grams of crude drug per ml, refrigerate at -5°C for 12 hours, add 0.2% activated carbon to the filtrate, boil for 20 minutes, then put it at -5°C for 30 hours, filter, and adjust the pH To 7, filter with a vertical melting funnel and a microporous membrane (0.65 μm) respectively to obtain the active ingredient extract of Kudiezi.

[0025] Concentrate the above extract, and make Kudiezi dripping pills by using the drop...

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PUM

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Abstract

A kudiezi medicinal preparation for treating cerebrovascular and ophthalmology diseases, wherein the medicinal preparation includes kudiezi spray-drying powder injection, high capacity fluid infusion, injection, tablet, capsule, granula, oral liquid, pill. The process for making the preparation can be realized by the conventional preparation process, or by the nano techniques.

Description

Technical field: [0001] The invention relates to a kudiezi pharmaceutical preparation and a preparation process thereof, and belongs to the technical field of medicine and its preparation. Background technique: [0002] Kudiezi, also known as Kudian Kudian, its main ingredients are adenosine and flavonoids. The pharmaceutical preparation prepared with Kudiezi has a definite mechanism of action and has the following advantages: it can treat multiple diseases, the onset time is similar to that of commonly used heart and cerebrovascular chemicals, and the curative effect is long-lasting, avoiding many toxic and side effects of chemicals; Increase cerebral blood flow, prevent cerebral thrombosis, and treat ischemic cerebrovascular diseases; have obvious inhibitory platelet aggregation, antithrombotic effects, and improve blood rheology; can reduce the size of myocardial infarction and reduce myocardial oxygen consumption; increase coronary artery Blood flow, reduce peripheral v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P9/00A61P27/02
Inventor 崔彬
Owner 崔彬
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