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Compound traditional Chinese medicine prepn. for treating symptom of delayed giving-up of opium, and its application

A compound preparation, a technology for withdrawal symptoms, applied in the field of traditional Chinese medicine compound preparations, to achieve the effects of protecting neurons, good social benefits, and reversing damage

Inactive Publication Date: 2004-10-20
亚宝药业太原制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, traditional Chinese medicine has been used to control acute withdrawal symptoms, but there is no report of further research on traditional Chinese medicine that is in line with my country's national conditions and can effectively control protracted withdrawal symptoms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The preparation of embodiment one Guiyuan sheet

[0013] prescription :

[0014] 5 parts of Ginseng, 16 parts of Yuanhu, 25 parts of Astragalus, 5 parts of Angelica, 6 parts of Ophiopogon japonicus

[0015] method :

[0016] 1. Properly crush 5 parts of Angelica sinensis in the recipe, distill with water steam for 4 hours, collect about 20ml of volatile oil, absorb the volatile oil on an appropriate amount of micro-powder silica gel, evaporate to dry at room temperature, and pass through an 80-mesh sieve for later use;

[0017] 2. The residue of Angelica sinensis after steam distillation and 15 parts of Astragalus (reserve 1 part for later use) and Ophiopogon japonicus (35 parts by weight) in the above prescription are properly crushed and boiled for 2 hours with four times the amount of water for the first time. Add 3 times the amount of water twice to decoct for 1.5 hours, warm filter, combine the filtrates, and evaporate to dryness to obtain 5.9 parts of Part ...

Embodiment 2

[0022] Example 2 Effect of Guiyuan Tablets on Behavioral Sensitization to Morphine in Mice

[0023] 1. Test drug:

[0024] Guiyuan Tablets, developed by the Institute of Basic Medical Sciences, Academy of Military Medical Sciences; Guiyuan Tablets powder for experiments, containing 12g of crude drug per g, prepared into a solution of the required concentration with distilled water; administration volume: 10ml / kg, administration route: intragastric administration .

[0025] 2. Reagents:

[0026] Morphine hydrochloride, produced by Qinghai Pharmaceutical Factory.

[0027] 3. Animals:

[0028] Kunming mice, grade 2, weighing 18-22 g, half male and half male, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences.

[0029] 4. Experimental method

[0030] 1. Determination of mouse activity

[0031] After the animals are administered, they are immediately put into a small animal autonomous activity detector to measure the activity of t...

Embodiment 3

[0086] Example 3 Guiyuan Tablets Clinical Curative Effect Study on Jiyan Symptoms

[0087] 1. Research Methods

[0088] 1. Inclusion criteria

[0089] (1) First explain the purpose of the experiment to the patient, and the patient agrees to participate in this research

[0090] (2) Patients who meet the DSM-IV (Diagnostic and Classification of Mental Disorders Manual, Fourth Edition) diagnostic criteria for opioid dependence after voluntary or compulsory acute detoxification, regardless of gender, aged between 18 and 55;

[0091] (3) Before entering the experiment, detailed physical examination and laboratory examination are required to exclude mental diseases and serious physical diseases, such as hepatitis, tuberculosis, etc.

[0092] (4) All are hospitalized patients

[0093] 2. Exclusion criteria

[0094] (1) Severe heart, liver, kidney damage or other serious physical diseases, such as tuberculosis, severe malnutrition, etc.;

[0095] (2) Those with a history of seve...

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PUM

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Abstract

A Chinese medicine in the form of tablet or oral liquid for treating the syndrome caused by dropping opium is prepared from 5 Chinese-medicinal materials: ginseng, corydalis tuber, Chinese angelica root, astragalus root ophiopogon root. Its advantage is high curative effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation and its application for treating protracted withdrawal symptoms of opioids Background technique [0002] Opioid drug addiction is a chronic recurrent encephalopathy characterized by compulsive drug-seeking and drug use behaviors, and reasonable and effective drug treatment is the first step to help addicts get rid of drug troubles. At present, drug treatment is generally divided into two stages at home and abroad: the detoxification period and the rehabilitation period. The detoxification period is mainly to help addicts get rid of physical dependence on drugs. There are two types of commonly used drugs: ① opioid receptor agonists with decreasing substitution, such as methadone, buprenorphine, etc.; ② non-opioid receptor agonists for symptomatic Treatment; such as α2 receptor agonist clonidine or lofexidine, M cholinergic receptor antagonist scopolamine, 654-2 symptomatic tre...

Claims

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Application Information

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IPC IPC(8): A61P25/36
Inventor 杨征范明陈纪军
Owner 亚宝药业太原制药有限公司
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