Yang-strengthening solid Xianrong prepn and its prepn process

A technology of solid preparation and antler mushroom, which is applied in the field of antler mushroom aphrodisiac solid preparation and its preparation, can solve the problems of affecting the safe use of preparation patients, lack of safe and efficient drugs, poor drug stability, etc. Easy to produce and take

Active Publication Date: 2004-11-24
上海海虹实业(集团)巢湖今辰药业有限公司
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AI-Extracted Technical Summary

Problems solved by technology

However, there is a lack of safe, efficient, and long-term medications for the treatment of such diseases in modern chemical drugs. It is important to carry forward the traditional advantages of traditional Chinese medicine and develop traditional Chinese medicine preparations with stable preparations, safe medication, accurate dosage, controllable quality, and reliable curative effect. significance
[0003] The existing traditi...
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Method used

In the present invention used prescription contains bitter, astringent, fishy smell medical material, adopts β-cyclodextrin inclusion technology can effectively cover above-mentioned taste, is convenient to take, with bitter, astringent, fishy smell as investigation index, carries out Inclusion test, the results are shown in Table 3.
This Xianrong Zhuangya...
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Abstract

The Yang-strengthening solid medicine preparation, named Xianrong, is prepared with pilose antler, curculigo rhizome, epimedium, morinda root, wolfberry fruit and other three kinds of Chinese medicinal materials; and it features its supplementary material including beta-cyclodextrin, corrective stevioside or proteoglycan and plasticizer selected from mannitol, sorbic alcohol, xylitol, dextrin and lactose oligomer and the spray drying and dry pelletizing capable of maintaining the effective component completely and suitable for continuous GMP production. The medicine contains no cane sugar and preservative, is safe, without side effect, and has many other advantages.

Application Domain

Technology Topic

Examples

  • Experimental program(4)
  • Effect test(1)

Example Embodiment

[0025] Example 1:
[0026] Preparation of Xianrong Zhuangyang Chewable Tablets
[0027] 1. Weigh 12.5g of raw velvet antler (dehairing), 25g of Curculio, 50g of Epimedium, 25g of Morinda officinalis (salt), 25g of Cistanche, 50g of Chinese wolfberry, 10g of Acanthopanax senticosus extract, 50g of Polygonum multiflorum (made) .
[0028] 2. The above eight flavors, take Polygonum multiflorum, Epimedium, Morinda officinalis, Lycium barbarum, Cistanche cistanche, and Curculio cistanche, reflux with 8 times the amount of 35% ethanol and extract twice, the first time is 6 hours, the second time is 4 hours, and combined extraction After the filtrate is concentrated to an appropriate amount, ethanol is added, stirred, allowed to stand, filtered, and ethanol is recovered to obtain concentrated solution A with a relative density of 1.06-1.12 at 50°C;
[0029] 3. Steam the velvet antler in a pot for 30-40 minutes, take out the slices, soak in an appropriate amount of 10 times 40% ethanol for more than 12 hours, and then use 8 times the amount of 40% ethanol to reflux for 4 times, followed by 3, 3, 2 , 2 hours, combine the extracts, filter; add appropriate amount of ethanol to the concentrate, stir, stand, filter, the filtrate recovers ethanol, the precipitate is washed with 60% ethanol until colorless, the lotion is allowed to stand, the ethanol is recovered, and concentrated Obtain concentrated solution B with a relative density of 1.10 at 50℃, add acanthopanax senticosus extract, concentrated solution A, and concentrated solution B to mix evenly; 4. Add 60g of inclusion agent β-cyclodextrin, and 4g of steviol glycoside as a corrective agent. Stir evenly, add 60g of mannitol, a forming agent, stir evenly, filter, and perform spray drying. The hot air inlet temperature is 170°C, the outlet temperature is 70°C, and the material is dry-granulated at a temperature of ≤60°C, and granulated. 120g of brown-yellow granules, 100 tablets.

Example Embodiment

[0030] Example 2: Preparation of Xianrong Zhuangyang Tablets
[0031] The preparation process is the same as in Example 1, except that in step 4 above, only 60 g of dextrin is added as a forming agent. Stir uniformly, filter, and pass in hot air in the spray state for spray drying. The hot air inlet temperature is 170-180°C, the outlet temperature is 70-80°C, and the material is dry-granulated at a temperature of ≤60°C. Granules to obtain 70 g of brown granules, which are pressed into 200 tablets.

Example Embodiment

[0032] Example 3: Preparation of Xianrong Zhuangyang Capsules
[0033] The preparation process is the same as in Example 2, except that the granules are filled into capsules to obtain 200 capsules.
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Description & Claims & Application Information

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