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Houttuynia cordata sodium cyclodextrin dressing material, preparation and preparing method thereof

A new houttuyfonate sodium and cyclodextrin inclusion compound technology, which is applied in the field of medicine, can solve the problems of inestimable potential risks and achieve the effects of improved stability, low toxic and side effects, and high drug content

Inactive Publication Date: 2004-12-08
毛友昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some animal safety test data are attached in this patent, the potential danger of intravenous injection in human body is still unpredictable.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Preparation of neohouttuyfonate sodium β-cyclodextrin inclusion complex: weigh neohouttuyfonate sodium and β-cyclodextrin according to the above ratio, add appropriate amount of water / ethanol and water, heat and stir , cooled to room temperature, filtered to obtain a solution, and the obtained solution was vacuum-dried / freeze-dried / spray-dried to obtain the inclusion compound of neohouttuydin sodium β-cyclodextrin.

Embodiment 2

[0021] Example 2: Preparation of hydroxypropyl-β-cyclodextrin inclusion complex of neohouttuyfonate sodium: weigh neohouttuyfonate sodium and hydroxypropyl-β-cyclodextrin according to the above proportions for later use. Hydroxypropyl-β-cyclodextrin was stirred and dissolved with an appropriate amount of water, and another new houttuyfonate sodium was added to the above solution, stirred, filtered with a 0.45μ membrane, and then filtered with a 0.22μ membrane, and the obtained solution was passed through After vacuum-drying / spray-drying / freeze-drying, a white powder is obtained, which is neohouttuyfonate sodium hydroxypropyl-β-cyclodextrin inclusion compound.

Embodiment 3

[0022] Example 3: Preparation of Neohouttuyfonate Sodium Hydroxypropyl-β-cyclodextrin: Neohouttuyfonate Sodium and Hydroxypropyl-β-cyclodextrin were weighed according to the above comparative amounts for later use. Hydroxypropyl-β-cyclodextrin was stirred and dissolved with an appropriate amount of water, and new houttuyfonate sodium was added to the above solution, ultrasonicated for 20-180 minutes, filtered with a 0.45 μm membrane and then filtered with a 0.22 μm membrane to obtain After vacuum-drying / spray-drying / freeze-drying, a white powder is obtained, which is neohouttuydin sodium hydroxypropyl-β-cyclodextrin inclusion compound.

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PUM

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Abstract

An inclusion compound is prepared from sodium neohouttuyfonate and beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin. It can be made into orally applied medicine, suppository, spray, or injection. It sadvantages are high solubility, stability and curative effect, and low by-effect.

Description

technical field [0001] The present invention relates to the technical field of medicine, specifically, it uses β-cyclodextrin or hydroxypropyl-β-cyclodextrin to form an inclusion complex with neohouttuydin sodium or adds β-cyclodextrin or hydroxypropyl - β-cyclodextrin to improve the solubility and stability of neohouttuydin sodium in water, so as to make β-cyclodextrin inclusion compound and its preparation. Background technique [0002] Neohouttuydin Sodium is the sodium bisulfite adduct of lauryl acetaldehyde, which has obvious inhibitory effect on Diplococcus pneumoniae, Salmonella typhi, Staphylococcus aureus, Escherichia coli and Sporothrix. It can improve the body's immunity, enhance the phagocytosis of white blood cells in patients, increase the level of serum properdin, and improve the body's non-specific immunity. It is mainly used to treat pelvic inflammatory disease, adnexitis, chronic cervicitis and other gynecological inflammations. It...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K9/19A61K9/20A61K9/48A61K31/255A61K47/02A61K47/06A61K47/40
Inventor 毛友昌毛晓敏
Owner 毛友昌