Preparation of solanine and its use in medicine

The technology of solanamine and solanine is applied to the preparation of solanine and the application field of solanine in medicine, and can solve the problems of rising, and the related information of the preparation method of solanine has not yet been found, and the like, To achieve the effect of high product purity, rich and cheap raw material sources, and strong pharmacodynamic activity

Inactive Publication Date: 2004-12-08
刘良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At home and abroad, there are chemical components of Solanum nigrum, Solanum solanum and Solanum japonica, the separation and detection method of solanamine and its anti-S 180 , anti-i

Method used

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  • Preparation of solanine and its use in medicine
  • Preparation of solanine and its use in medicine
  • Preparation of solanine and its use in medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Preparation of Australian Solanamine with Solanum nigrum as raw material

[0048] With reference to Fig. 1, prepare the preparation method of Australian solanamine with nightshade fruit as follows:

[0049](1) Weigh 500kg of Solanum nigrum fruit harvested from mid-October to late October to remove impurities, pulverize solid-liquid separation with a refiner to obtain fruit juice and pomace, and soak Solanum solanum pomace with 3% acetic acid aqueous solution 2 times, solid-liquid weight ratio 1:1, solid-liquid separation to obtain infusion, combined juice and infusion, set aside to settle, take supernatant and heat to boiling, remove floating green colloid, filter and cool, place filtrate to settle, take When the supernatant was heated to 80°C, concentrated ammonia water was added to pH 8, the supernatant was removed by cooling and sedimentation, and the turbid liquid was centrifuged for solid-liquid separation to obtain the crude total alkaloids of Solanum ni...

Embodiment 2

[0053] Example 2 Preparation of Australian solanamine with yellow fruit eggplant as raw material

[0054] Take 500kg of yellow solanum fruit, according to the preparation method of Example 1, 182g of Australian solanamine is obtained, and the purity measured by high performance liquid chromatography is 98.7%.

Embodiment 3

[0055] Example 3 Preparation of Australian Solanamine with Australian Solanum as Raw Material

[0056] Take 500kg Australian solanum fruit, according to the preparation method of Example 1, obtain 137g Australian solanamine, and the purity measured by high performance liquid chromatography is 99.0%.

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Abstract

A process for preparing solasodine includes such steps as mixing alpha-solasonine, beta-solasonite, gamma-solasonine and solamargine and hydrolyzing. It can be used to prepare the anticancer and anti-inflammatory medicines.

Description

technical field [0001] The invention relates to a preparation method of solanamine and the application of solanamine in medicine. Background technique [0002] At home and abroad, there are chemical constituents of Solanum nigrum, Solanum solanum and Solanum solanum, the separation and detection method of solanamine and its anti-S 180 , anti-inflammatory, and blood sugar-raising effects, but there is no relevant information on the preparation method of Australian solanamine and the application of Australian solanamine in medicine. Contents of the invention [0003] The invention provides a method for preparing solanamine with anti-cancer and anti-inflammatory drug activity, less toxic and side effects, simple and convenient preparation method, high purity and strong drug activity, and using solanamine as a class of traditional Chinese medicine for anti-cancer 1. The application of new drug sources of anti-inflammatory dr...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P11/06A61P29/00A61P35/00C07J71/00
Inventor 刘良刘芯辰崔淑华
Owner 刘良
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