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Freeze-dried Danhong powder injection for injection and its preparing method

A technology for freeze-dried powder injection and injection, which is applied in the field of freeze-dried powder injection for Danhong injection and its preparation, which can solve the problems of inconvenient transportation, low active ingredient content, and poor purification effect of injection liquid, and achieve Effects of whole blood viscosity improvement, low water content, and long storage time

Inactive Publication Date: 2004-12-15
北京干露春科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current ministerial standard adopts the method of extracting Danshen dilute with alcohol and then co-water-extracting with safflower. The purification effect is not good, and the content of its active ingredients is not high, which is a great waste of medicinal materials. There are problems such as inconvenient transportation and poor quality stability, which need to be improved to provide better medicines for clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment one: specification 1000 bottles

[0069] (1) 1500 g of Salvia miltiorrhiza was crushed, extracted twice with alkaline water with a pH of 10 or more at a temperature of 80°C, the first time was 60 minutes, the second time was 120 minutes, and the combined extract was extracted as extract A;

[0070] (2) 500 g of safflower, reflux extraction with 40% ethanol for 3 times, each time for 90 min, recover ethanol until no alcohol smell, and obtain extract B;

[0071] (3) Add 5 times the amount of water to the safflower dregs extracted with ethanol, extract 3 times with acid water with a pH of 3 to 5, the temperature is 20°C, and each time is 120 minutes, and combine the extracts to obtain extract C;

[0072] (4) Combine the extracts A and C, centrifuge, take the supernatant, concentrate under reduced pressure, adjust the pH to 6.5-7, put on the macroporous resin, wash with deionized water until there is no Molish reaction, and continue to wash with 20% ethanol until...

Embodiment 2

[0074] Embodiment two: specification 100 bottles

[0075] (1) 150 g of Salvia miltiorrhiza was crushed, extracted three times with alkaline water with a pH of 10 or higher, at a temperature of 80° C., for 60 minutes each time, and combined the extracts into extract A;

[0076] (2) 50 g of safflower, extracted twice with 80% ethanol under reflux, each time for 60 minutes, recovered the ethanol until there was no alcohol smell, and obtained the extract B;

[0077] (3) Add 50 times the amount of water to the safflower dregs extracted with ethanol, extract twice with acid water with a pH of 3 to 5, and extract twice at a temperature of 80°C for 30 minutes each time, and combine the extracts to obtain extract C;

[0078] (4) Combine the extracts A and C, centrifuge, take the supernatant, concentrate under reduced pressure, adjust the pH to 6.5-7, put on the macroporous resin, wash with deionized water until there is no Molish reaction, and continue to wash with 90% ethanol until it...

Embodiment 3

[0080] Embodiment three: 500 bottles of specifications

[0081] (1) 750 g of Salvia miltiorrhiza was crushed, extracted twice with alkaline water with a pH of 10 or higher, at a temperature of 100°C, for 60 minutes each time, and the combined extracts were extracted as extract A;

[0082] (2) 250 g of safflower, extracted twice with 60% ethanol under reflux, each time for 90 minutes, recovered the ethanol until there was no alcohol smell, and obtained the extract B;

[0083] (3) Add 10 times the amount of water to the safflower dregs extracted with ethanol, extract 3 times with acid water with a pH of 3 to 5, at a temperature of 40°C, for 90 minutes each time, and combine the extracts to obtain extract C;

[0084] (4) Combine the extracts A and C, centrifuge, take the supernatant, concentrate under reduced pressure, adjust the pH to 6.5-7, put on the macroporous resin, wash with deionized water until there is no Molish reaction, and continue to wash with 40% ethanol until it i...

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Abstract

The present invention features that based on the property of total salvianolic acid, which is a kind of weak acid, may be reacted with alkali to form salt with high stability and has high dissolvability in water; red sage is first extracted with alkali solution and then extracted with resin column, and safflower is ethanol refluxed to maintain its chalcone dimmer and other effective component and then acid solution extracted; and the safflower extract liquid and the red sage extract liquid are finally resin column extracted to raise the content of salvianolic acid, flavone and other effective components. The present invention provides a kind of red freeze dried sage-safflower powder for injection for clinical application in treating coronary heart disease, angina pectoris, cerebral vascular diseases and other diseases.

Description

[0001] Field [0002] The invention belongs to the field of traditional Chinese medicine pharmacy, and specifically relates to a danhong injection freeze-dried powder containing effective parts of salvia miltiorrhiza and safflower and a preparation method thereof. Background technique [0003] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza, according to the existing literature: Salvia miltiorrhiza was first recorded in "Shen Nong's Materia Medica", and many herbal medicines have been recorded in successive dynasties. Indications are: "dispelling blood stasis and relieving pain, promoting blood circulation and promoting menstruation, clearing heart and eliminating troubles. It is used for irregular menstruation, amenorrhea dysmenorrhea, accumulation of lumps, tingling pain in chest and abdomen, sore swelling and pain, upset and insomnia; hepatosplenomegaly, angina pectoris" . It shows that Salvia miltiorrhiza has various effects in clinical application....

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/352A61P9/10
Inventor 张晴龙
Owner 北京干露春科技有限公司
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