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Use of cnidium fruit element in medicine of treating skin pruritus and the medicine preparation method

A technology for skin pruritus and osthole, which is applied to skin diseases, drug combinations, active ingredients of heterocyclic compounds, etc., can solve the problems of low utilization rate of active ingredients, waste of medicinal materials, difficult treatment, etc., and achieves remarkable curative effect and total yield High and simple effect of refining process

Inactive Publication Date: 2004-12-29
周然 +2
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AI Technical Summary

Problems solved by technology

The treatment needs to be decocted, filtered and kept at the temperature of the liquid medicine, which is very inconvenient for the patient; for some parts that are not easy to be fumigated, the treatment is more difficult
Due to the low utilization rate of active ingredients in the liquid medicine, the waste of medicinal materials is caused
[0004] Osthole is a monomer extracted from the fruit of Umbelliferae Cnidium, and there is no relevant report on its clinical application in skin pruritus and skin pruritus caused by acute and chronic dermatitis

Method used

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Examples

Experimental program
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Embodiment Construction

[0020] The preparation method of the medicine for treating skin pruritus and skin pruritus caused by acute and chronic dermatitis with osthole is as follows:

[0021] 1. Extraction: Weigh 2Kg of Cnidium chinensis medicinal material, crush it into coarse powder, add 5 times the amount of ethanol to cold soak for 12 hours, filter, repeat three times, combine the filtrate, recover ethanol, and concentrate the extract to about 1L.

[0022] 2. Separation: Put 1L of the above-mentioned extraction concentrate at room temperature to stand for stratification, discard the water layer, extract the oil layer with an equal volume of petroleum ether (boiling range 60-90°C) three times, combine the petroleum ether layer, and stand at room temperature Crystallization, after a large amount of crystals are precipitated, the crystals are collected for later use.

[0023] 3. Refining: Repeatedly recrystallize the above crude crystals three times with absolute ethanol, collect the crystals, and ob...

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PUM

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Abstract

The present invention is the application of osthole in prepare medicine for treating pruritus caused by acute and chronic dermatitis. Osthole is obtained through the technological process of ethanol extraction, petroleum separation and refining; and is used as active component in preparing medicine liquid or medicine ointment for treating pruritus caused by acute and chronic dermatitis via combination with excipient and / or carrier. The preparation contains osthole in 0.1-10 wt%. The preparation process is simple, stable in quality, high in total yield. Pharmacological and toxicologic experiments show that the medicine has the functions of stopping itching, eliminating inflammation and resisting type-I and type-IV allergic reaction, no acute toxicity, no skin irritation, no hypersusceptibility, and obvious curative effect on pruritus caused by acute and chronic dermatitis.

Description

technical field [0001] The invention relates to the application of osthole in treating skin pruritus and skin pruritus caused by acute and chronic dermatitis and a preparation method of the medicine. Background technique [0002] Acute and chronic dermatitis is a common disease in dermatology, and skin pruritus is one of its main symptoms; skin pruritus refers to a skin disease that has no primary damage to the skin, only itching and the secondary damage caused by it, It is more common in middle-aged and elderly people, and the incidence rate is higher. In the above-mentioned diseases, the patient scratches due to unbearable itching, which often causes hyperemia, skin scratches, lichenification, pigmentation and other damages in the secondary lesion, and may also cause insomnia or restless sleep due to itching. This not only troubles the majority of patients, but also a difficult problem for dermatologists. At present, the western medicines clinically used to treat skin pr...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61P17/04
Inventor 周然王永辉李艳彦冯玛莉李培毅武玉鹏贾力莉牛艳艳彭涛
Owner 周然
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