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Chinese compound prescription for treating osteoporosis and its preparing process

A technology of osteoporosis and traditional Chinese medicine, applied in the field of medicine, can solve the problems of large side effects, high price, uncertain long-term curative effect, etc., achieve the effect of less toxic side effects, safe medication, and reduce bone loss

Inactive Publication Date: 2004-12-29
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as long-term use of side effects (such as estrogen, etc.), uncertain long-term efficacy (such as fluoride, etc.), expensive (such as active vitamins, calcitonin, etc.), etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Epimedium (100g), Cnidium (50g), Drynaria (50g), Salvia (50g)

[0021] Take the above medicinal materials respectively, add 8 times the amount of 75% ethanol to each, soak for 12 hours, heat and reflux for extraction for 1 hour, let cool and filter to obtain the extracts of Epimedium, Cnidium, Rhizoma Drynariae and Salvia miltiorrhiza respectively. Add 8 times the amount of ethanol to the medicinal residues, perform the same operation twice as before, combine the extracts obtained three times, concentrate, dry and pulverize them into fine powders to obtain the alcohol extracts of the four medicinal materials respectively. Mix the alcoholic extract fine powder of the four medicinal materials evenly, after sieving, add appropriate amount of starch and lactose powder to make granules, test and pack, each bag is about 5.0g.

Embodiment 2

[0023] Epimedium (100g), Cnidium (50g), Drynaria (50g), Salvia (50g)

[0024] Take the above medicinal materials, add 8 times the amount of 75% ethanol, soak for 12 hours, extract under reflux for 1 hour, let cool and filter to obtain an extract. Add 8 times the amount of ethanol to the medicinal residues, perform the same operation twice as before, combine the extracts obtained three times, concentrate, dry, and pulverize into fine powder. The above extract was added to the resin column to wash the impurities with water and 10% alcohol until colorless, and continued to be eluted with 50% alcohol. The eluate was concentrated, dried, and pulverized into fine powder. After sieving the fine powder, add appropriate amount of starch, lactose and talc to granulate, put into hard capsules, each capsule is about 0.5g, inspect and package.

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PUM

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Abstract

The present invention is the recipe and preparation process of osteoporosis treating Chinese medicine, and the medicine features less toxic side effect and safety in use. The medicine is prepared with epimedium 5-50 wt%, drynaria rhizome 5-50 wt%, cnidium fruit 5-50 wt%, and red sag 5-50 wt%. The technological process of preparing the medicine includes thrice extracting dried medicine material with solvent of 6-10 times via heating at the boiling point of the solvent for 1-3 hr each, merging the extractive liquid, concentration, drying and crushing into fine powder. The process is scientific, stable and suitable for industrial production, and the present invention provides one new way for treating osteoporosis.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a small traditional Chinese medicine compound used for treating osteoporosis and a preparation method thereof. Background technique: [0002] Osteoporosis is a systemic metabolic bone disease characterized by decreased bone mass and degeneration of the microstructure of bone tissue as the main pathological features, resulting in increased bone fragility and increased fracture risk. Pain, easy fracture, and shortened height are the main manifestations. At present, it can be divided into two types: primary osteoporosis and secondary osteoporosis. Primary osteoporosis is characterized by decreased bone mineral content and fractures, accounting for more than 95% of the incidence. A common type; secondary osteoporosis accounts for about 5% of the incidence, mainly caused by various diseases such as renal bone disease, hyperthyroidism, diabetes and acidosis, and iatrogenic diseases....

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/20A61K9/48A61P19/10
Inventor 李发美孟繁浩梁茂新刘英华李遇伯熊志立
Owner SHENYANG PHARMA UNIVERSITY