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Medicine for treating hemicrania

A migraine and drug technology, applied in the field of migraine drugs, can solve the problems of not being able to quickly relieve migraine symptoms, not being able to fully target the pathogenesis of migraine, first-pass blood-brain barrier obstruction, etc., to achieve the reduction of acetic acid The number of writhing reactions, significant synergy, and the effect of increasing pain threshold

Inactive Publication Date: 2005-01-05
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, most patients suffer from pathogenic factors caused by wind pathogens and poor blood flow as the basis of the pathogenesis, so extinguishing the wind and resolving phlegm, replenishing qi and activating blood cannot completely hit the root of the pathogenesis of migraine
[0007] (3) Traditional oral administration methods are adopted for various drugs. Drugs are slowly absorbed in the gastrointestinal tract. In addition, due to the first-pass effect of the liver and the hindrance of the blood-brain barrier, the effective ingredients reach the lesion in the brain very slowly. It is also very rare, thus affecting the clinical curative effect, and the onset of effect is also slow, and it cannot achieve the effect of rapidly relieving migraine symptoms.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0229] Weigh the raw materials according to the following ratio:

[0230] Xu Changqing 1500g Angelica dahurica 1000g Notopterygium 1000g

[0231] The production method is as follows:

[0232] Take Xu Changqing, Angelica dahurica and notopterygium, dry and pulverize to 120 mesh fine powder, add 30% sodium chloride solution 75000ml, distill and recover distillate 3500ml, concentrate to 4.5g crude drug / ml, add solubilizer, sterilize and bottle spare.

[0233] Usage and dosage: Administer through the nasal cavity, drop the drug solution on a cotton ball to plug the nose, plug the right nose for left headache, plug the left nose for right headache, use the left and right noses alternately for all headaches, 30 minutes each time. Four times a day, 0.25ml each time. 30 days is a course of treatment. Medications may be given temporarily during headache attacks.

Embodiment 2

[0235] Weigh the raw materials according to the following ratio:

[0236] Xu Changqing 2200g Angelica dahurica 800g Notopterygium 700g

[0237] Take Xu Changqing, Angelica dahurica and notopterygium, dry and pulverize to 120 mesh fine powder, add 30% sodium chloride solution 75000ml, distill and recover distillate 3500ml, concentrate to 3.7g crude drug / ml, add solubilizer, sterilize and bottle spare.

[0238] Usage and dosage: Administer through the nasal cavity, drop the drug solution on a cotton ball to plug the nose, plug the right nose for left headache, plug the left nose for right headache, use the left and right noses alternately for all headaches, 30 minutes each time. Four times a day, 0.25ml each time. 30 days is a course of treatment. Medications may be given temporarily during headache attacks.

Embodiment 3

[0240] Weigh the raw materials according to the following ratio:

[0241] Xu Changqing 1000g Angelica dahurica 500g Notopterygium 500g

[0242]Take Xu Changqing, Angelica dahurica and notopterygium, dry and pulverize to 120 mesh fine powder, add appropriate amount of dextrin and auxiliary materials to make 2100g granules, pack into bags, 7g / bag.

[0243] Usage and dosage: Take orally, one bag each time, three times a day.

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PUM

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Abstract

A Chinese medicine for treating hemicrania is prepared from paniculate swallow wort root, dahurian angelica root and notopterygium root.

Description

[0001] 1. The technical fields mentioned [0002] The invention relates to a medicine for treating migraine, in particular to a Chinese patent medicine prepared from Chinese herbal medicines. 2. Background technology [0003] Migraine is a recurrent clinical common disease, the prevalence of migraine is relatively high, about 985.2 / 100,000 / year, 8% of men and 25% of women will suffer from this disease in their lifetime. Although my country's epidemiological survey did not find any mortality, its frequent outbreaks have seriously affected the patients' physical and mental health, daily life, work and study. [0004] At present, there are mainly the following problems in the treatment of migraine both at home and abroad: [0005] (1) Western medicine treatment of this disease is mostly symptomatic treatment such as analgesia, sedation, and antiemetic. Most of them use ergotamine preparations and triptans. These drugs often have dizziness, nausea, lethargy, gastrointestinal irri...

Claims

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Application Information

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IPC IPC(8): A61P25/06
Inventor 王新陆
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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