Method for synthesizing m-methoxybenxaldenhyde

A synthesis method, m-bromobenzaldehyde technology, applied in the field of catalytic preparation of m-methoxybenzaldehyde, can solve the problems of difficult industrialization, high cost, high energy consumption, etc., and achieve the advantages of simple operation, low energy consumption, and improved utilization rate Effect

Inactive Publication Date: 2005-01-12
EAST CHINA UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a low-cost method for synthesizing m-methoxybenzaldehyde, which overcomes the defects of high cost, high energy consumption, large pollution and difficulty in industrialization in the prior art, so that large-scale industrial production can be realized. to meet the needs of industry sectors

Method used

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  • Method for synthesizing m-methoxybenxaldenhyde

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Add 2.5 grams of dimethylformamide to 36 grams of 30% sodium methoxide methanol solution, then add 1 gram of cuprous chloride and 18.5 grams of m-bromobenzaldehyde, and heat up to 125° C. for 2 hours. Add acid to neutralize to neutral, remove insoluble solid matter by filtration, distill off methanol, and distill the residue under reduced pressure to collect m-methoxybenzaldehyde components to obtain 13.2 grams of m-methoxybenzaldehyde. The yield is greater than 96%.

Embodiment 2

[0020] Add 5 grams of dimethylformamide to 108 grams of 10% sodium methoxide methanol solution, then add 1 gram of cuprous chloride and 18.5 grams of m-bromobenzaldehyde, and heat up to 125° C. for 2 hours. Add acid to neutralize to neutral, remove insoluble solid matter by filtration, distill off methanol, and distill the residue under reduced pressure to collect m-methoxybenzaldehyde components to obtain 13 grams of m-methoxybenzaldehyde. The yield is greater than 95%.

Embodiment 3

[0022] Add 2.5 grams of dimethyl sulfoxide to 36 grams of 30% sodium methoxide methanol solution, then add 1 gram of cuprous oxide and 18.5 grams of m-bromobenzaldehyde, and heat up to 125° C. for 2 hours. Add acid to neutralize to neutral, remove insoluble solid matter by filtration, distill off methanol, and distill the residue under reduced pressure to collect m-methoxybenzaldehyde components to obtain 12.4 g of m-methoxybenzaldehyde. The yield is greater than 91%.

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Abstract

With the solvent of methanol and secondary solvent of non-protonic solvent, m-bromo-benzoyl formaldehyde reacts with sodium methoxide, using cuprous salt as catalyst. Then the product is under vacuum distillation to produce product contg. 98% of m-methoxyphenyl formaldehyde. Said invention process ha advantages of: short reaction time, simple operation, high yield, high utilization rate of reaction equipment, commercialization to be realized easily.

Description

technical field [0001] The invention relates to a synthesis method of m-methoxybenzaldehyde, in particular to a method for preparing m-methoxybenzaldehyde by catalytic method. Background technique [0002] m-methoxybenzaldehyde is an important intermediate in organic synthesis, widely used in the synthesis of drugs, pesticides, spices, dyes, fluorescent whitening agents, etc. For example, it is used to synthesize new isoxazole compounds with herbicidal function (Journal of Beijing Normal University, Natural Science Edition, 37(6), 787-789, 2001), and to synthesize 4H-chromene compounds with anticancer function (WO 2002092594 ), synthesis of quinazoline compounds with anti-cancer and anti-platelet functions (U.S. 6,479,499), synthesis of aromatase inhibitor flavanones (Pharmaceutical Research, 19(3), 286-291 2002), etc. [0003] The early synthesis method of m-methoxybenzaldehyde is: it is formed by the methylation of expensive m-hydroxybenzaldehyde, and m-hydroxybenzaldehyd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/64C07C47/575
Inventor 冀亚飞熊玉春许煦洪道广
Owner EAST CHINA UNIV OF SCI & TECH
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