Method for preparing procaine

A technology of procaine and Raney nickel, which is applied in the field of preparation of ester anesthetics, can solve the problems of expensive Pd/C catalyst, increased requirements for dangerous equipment, and limited application, etc., and achieves production cost reduction, The effect of short process route and convenient operation
CN1562961AInactive Publication Date: 2005-01-12NANJING UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING UNIV OF TECH
Publication Date
2005-01-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to a process for preparing procaine, by using p-nitrobenzoic acid and diethylamino ethanol as raw materials, by esterification to produce nitrocaine, which is then reduced by reductant of hydrogenin xylene solvent with catalyst of nicket compound (Leininie) in suitable temp. and pressure to produce final product-procaine. Advantages are simple process, high transforming rate, high yield, high pureness, short process, reutilization of catalyst, no three wastes.
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Description

technical field

[0001] The present invention relates to a preparation method of ester anesthetics, more specifically to a method for preparing procaine by catalytic hydrogenation. Background technique

[0002] Procaine (p-aminobenzoic acid-β-diethylaminoethyl ester) is a common ester local anesthetic and one of the basic drugs widely used in clinical practice at home and abroad. In clinical application, the irritation and side effects are small, the effect is good, and the absorption is fast and the anesthesia time is short. In recent years, its new clinical uses have been increasing, and the market demand has become more and more prosperous, which has attracted more and more attention.

[0003] The synthesis methods of procaine mainly include direct esterification and indirect esterification.

[0004] At present, the direct esterification method is mostly used in the production of procaine. The specific route is as follows:

[0005]

[0006] The direct esterification...

Claims

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