Arbidol containing compound preparation

A compound preparation, the technology of Arbidol, which is applied in the field of antiviral drug Arbidol hydrochloride compound preparation, can solve the problems of uncertain curative effect, side effects of amantadine, nasal congestion, sneezing, sore throat, etc.

Inactive Publication Date: 2005-02-02
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0030] It can be seen from Table 1 that fever, headache, general pain, fatigue, weakness, chest discomfort, and cough are common symptoms of influenza, and sometimes accompanied by nasal congestion, sneezing, and sore throat. Most of the compound cold medicines currently used clinically are For the above-mentioned symptoms of common cold or flu, there are few compound cold medicines that have antiviral effect and can fundamentally treat flu. Most of the antiviral ingredients are amantadine, which only has a certain effect on influenza A. Its curative effect is uncertain, and amantadine also has certain side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Embodiment one: Arbidol hydrochloride / ibuprofen granules (1g / bag)

[0081] (1) Formulation:

[0082] Particle I:

[0083] Arbidol Hydrochloride 50mg

[0084] Mannitol 435mg

[0085] Sucralose 0.7mg

[0086] yellow 6 # 1mg

[0087] 2% hydroxypropyl methylcellulose 60% alcohol solution appropriate amount

[0088] Particle II:

[0089] Ibuprofen 100mg

[0090] Mannitol 389mg

[0091] yellow 6 # 1mg

[0092] 2% hydroxypropyl methylcellulose 60% ethanol solution appropriate amount

[0093] Extras:

[0094] Sweet Orange Powder Flavor 20mg

[0095] (2) Operation steps:

[0096] ① Preparation of adhesive: mix yellow 6 # Dissolved in a small amount of water and mixed with 2% hydroxypropyl methylcellulose 60% ethanol solution;

[0097] ②Granulation I: Mix Arbidol hydrochloride crushed through a 100-mesh sieve with mannitol and sucralose in a mixing granulator, add an appropriate am...

Embodiment 2

[0100] Embodiment two: Arbidol hydrochloride / ibuprofen tablet (485mg / tablet)

[0101] (1) Formulation:

[0102] Particle I:

[0103] Arbidol Hydrochloride 100mg

[0104] Starch 30mg

[0105] Microcrystalline Cellulose 60mg

[0106] Cross-linked polyvinylpyrrolidone 2mg

[0107] 10% povidone 50% ethanol solution appropriate amount

[0108] Particle II:

[0109] Ibuprofen 150mg

[0110] Starch 40mg

[0111] Microcrystalline Cellulose 80mg

[0112] Cross-linked polyvinylpyrrolidone 3mg

[0113] 10% povidone 50% ethanol solution appropriate amount

[0114] Extras:

[0115] Magnesium Stearate 5mg

[0116] Coating material:

[0117] Opadry 15mg

[0118] (2) Operation steps:

[0119] ①Granulation I: Mix Arbidol hydrochloride crushed through a 100-mesh sieve with starch, microcrystalline cellulose, and cross-linked polyvinylpyrrolidone in a mixing granulator, and add an appropriate amount of 10% povidone 50% ethanol solution Granulate, dry at 50-55°C;

[0120] ②Granul...

Embodiment 3

[0123] Embodiment three: Arbidol hydrochloride / ibuprofen / pseudoephedrine hydrochloride tablet (500mg / sheet)

[0124] (1) Formulation:

[0125] Particle I:

[0126] Arbidol Hydrochloride 100mg

[0127] Starch 30mg

[0128] Microcrystalline Cellulose 60mg

[0129] Cross-linked polyvinylpyrrolidone 2mg

[0130] 10% povidone 50% ethanol solution appropriate amount

[0131] Particle II:

[0132] Ibuprofen 150mg

[0133] Pseudoephedrine Hydrochloride 15mg

[0134]Starch 40mg

[0135] Microcrystalline Cellulose 80mg

[0136] Cross-linked polyvinylpyrrolidone 3mg

[0137] 10% povidone 50% ethanol solution appropriate amount

[0138] Extras:

[0139] Magnesium Stearate 5mg

[0140] Coating material:

[0141] Opadry 15mg

[0142] (2) Operation steps:

[0143] ①Granulation I: Mix Arbidol hydrochloride crushed through a 100-mesh sieve with starch, microcrystalline cellulose, and cross-linked polyvinylpyrrolidone in a mixing granulator, and add an appropriate amount of 10%...

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PUM

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Abstract

The present invention relates to a compound preparation containing antiviral drug arbidol, which is especially adapted to respiratory tract infection disease caused by virus. During the respiratory tract infection period, the patient has the discomfort symptoms of fever and nose stuff, therefore, the anti influenza compound preparation on the invention also includes one, two or three of the ibuprofen, alcaine pseudoephedrine, and dextromethorphan hydrobromide on the basis of including alcaine arbidol, and is then added with take orally preparation medicinal adjuvant to make take orally solid dosage forms. The medical effect experiment shows that the cooperation of the active components in the compound preparation is well, and the preparation is convenient in used by patient.

Description

technical field [0001] The invention relates to a compound preparation of antiviral drug Arbidol hydrochloride, in particular to a compound preparation for treating influenza and various symptoms thereof. Background technique [0002] Influenza (influenza, referred to as influenza) is an acute respiratory infectious disease caused by influenza virus, and is one of the major public health problems faced by human beings. According to statistics, the annual incidence rate of influenza is 10% to 30%, and its epidemiological most notable features are: sudden outbreak, rapid spread, and widespread spread. Influenza epidemics have certain seasonality. It often occurs in winter in northern my country, while it occurs in winter and summer in the south. The incidence rate of influenza is high, and the crowd is generally susceptible. my country is a high-incidence area of ​​influenza, and three of the four worldwide pandemics in the 20th century originated in m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61P31/16
Inventor 刘振涛牛占旗刘立云申东民王莉芳陈玉洁王荣端冯小龙
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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