Polyvinylidene fluoride hollow fiber membrane for hemodialysis

A technology of polyvinylidene fluoride and hemodialysis, applied in the direction of semi-permeable membrane separation, membrane technology, suction equipment, etc., can solve problems such as inability to remove, achieve stable membrane dialysis speed, high permeation speed, and no increase in dialysis pressure Effect

Inactive Publication Date: 2005-02-16
TIANJIN MOTIAN MEMBRANE ENG & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The membrane has a high filtration flux but cannot remove β 2 - Low-molecular-weight protein harmful substances such as MG

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Polyvinylidene fluoride (SOLVAY 1015) 24wt%, DMA68wt%, polyethylene glycol 200003wt%, polyethylene glycol 200 5wt% were mixed uniformly at 80 ° C, after standing at 50 ° C for defoaming for 12 hours spinning. The main component of the coagulation bath liquid is water, add 2wt% of DMA solvent, the spinning and drafting speed is 25 m / min, the core of the spinning nozzle of the insertion tube is fed with nitrogen, and the obtained polyvinylidene fluoride hollow fiber membrane has an inner diameter of 0.2mm, and the fiber The wall thickness is 0.04mm, the inside of the hollow fiber is round and round, and there is no defect on the surface. Pure water penetration rate 270L / m 2 ·h·(0.10MPa)β 2 -Microglobulin penetration rate is 82%, human serum albumin retention rate is 99.2%.

Embodiment 2

[0029] Embodiment 2: Polyvinylidene fluoride (Kynar 461, the U.S.) 23wt%, DMA66wt%, polyvinylpyrrolidone 3wt%, polyethylene glycol 600 8wt% are mixed at 80 ℃, stand defoaming at 50 ℃ for 12 hours After spinning. Coagulation bath liquid water, spinning drafting speed 15 m / min, 25wt% DMA aqueous solution passed through the core of the insert tube spinning nozzle, the obtained polyvinylidene fluoride hollow fiber membrane has an inner diameter of 0.2 mm, a fiber wall thickness of 0.05 mm, and a hollow fiber The inner circle is round, the appearance is free of defects, and the pure water penetration rate is 300L / m 2 ·h·(0.10MPa)β 2 -Microglobulin penetration rate is 83%, human serum albumin retention rate is 99.2%.

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Abstract

The invention relates to hollow a fibre membrane of polyvinylidene fluoride used for hemodialysis. Thickness of the membrane is 10-50micon and bore is 100-500 micron. The membrane is made of polyvinylidene fluoride resin of 15-35 percent, filature impregnant of 60-80 percent, hydrophilicity macromolecule of 1-5 percent and spinning raw liquor of 1-9 percent. It is made by dry-jet wet-spinning process. The hydrophilicity macromolecule includes polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidon and (or) polyvinyl chloride. Spinning solvent is polar solvent.

Description

Technical field: [0001] The invention relates to a polyvinylidene fluoride hollow fiber membrane which can be used for hemodialysis and a manufacturing method thereof. Background technique [0002] In the prior art, artificial kidneys made of copper ammonia fiber and other materials are often used, but because they cannot remove β 2 - microglobulin, long-term use of such an artificial kidney by the patient will lead to dialysis, thereby increasing the suffering of the patient. [0003] Moreover, since blood contains components such as blood cells and proteins, during hemodialysis, the above-mentioned substances will easily lead to a decrease in the membrane flux of the filtration membrane, so people have been looking for membranes that are not easy to adsorb proteins, and are not easy to form cohesive protein layers on the membrane surface. Dialysis membrane with smooth surface and little pressure rise during membrane filtration. [0004] For example, Japanese Patent Laid-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/18B01D69/08B01D71/34
Inventor 吕晓龙
Owner TIANJIN MOTIAN MEMBRANE ENG & TECH
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