Preparation of flavone glycoside from scutellaria root

A technology of total flavonoid aglycone and scutellaria baicalensis, applied in the direction of preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., to achieve the effect of high purity, good stability and reproducibility, and simple process

Inactive Publication Date: 2005-02-23
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as: Hu Buchao scholar [Northwest Pharmaceutical Journal, 4 (2): 31 (1989)] prepares baicalein with this method, even if what raw material uses is baicalin, also can only obtain the baicalein that yield is 5%
The use of concentrated acid will have a series of adverse effects on industrial production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 1Kg of Scutellaria baicalensis coarse powder, add 1 times the amount of water and mix well, heat it at 37°C for 1 hour, dry it at 60°C for 6 hours, extract it once with methanol under reflux, and recover the solvent to obtain the total flavonoid aglycone extract of Scutellaria baicalensis .

[0014] Implementation effect: yellow total flavonoid aglycone with a weight of about 80 g and a content of >45% is obtained. The yield of total flavone aglycone is 8%, and the content is higher than 45%.

Embodiment 2

[0016] Take 1 kg of Scutellaria baicalensis coarse powder, mix it with 2 times the amount of water, heat it at 37°C for 2.5 hours, dry it at 60°C for 6 hours, extract it twice with ethanol under reflux, and recover the solvent to obtain the total flavonoid aglycone extract of Scutellaria baicalensis.

[0017] Implementation effect: yellow total flavonoid aglycone with a weight of about 80 g and a content of >45% is obtained. The yield of total flavone aglycone is 8%, and the content is higher than 45%.

Embodiment 3

[0019] Take 1 kg of Scutellaria baicalensis coarse powder, mix it with 3 times the amount of water, heat it at 37°C for 4 hours, dry it at 60°C for 6 hours, extract it with acetone reflux for 3 times, and recover the solvent to obtain the total flavonoid aglycone extract of Scutellaria baicalensis.

[0020] Implementation effect: yellow total flavonoid aglycone with a weight of about 75 g and a content of >61% is obtained. The yield of total flavone aglycone is 7.5%, and the content is higher than 60%.

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PUM

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Abstract

Total flavone aglycone in baikal skullcap root, which is used in Chinese medicine industry, is produced by: crushing baikal skullcap root, adding water 1-3 times, enzyme hydrolyzing at 37deg.C for 1-4 hours, drying, reflux extracting 1 to 3 times with organic solvent, recovering solvent to obtain total flavone aglycone extracts of baikal skullcap root. Compared with prior arts, its advantages includes: high extractive rate of effective ingredients, high purity and stability, good reproduction quality, simple process, no use for special equipment and suitable for production.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicines, in particular to a preparation method of total flavonoid aglycone in Scutellaria baicalensis. Background technique [0002] Scutellaria baicalensis is the dried root of Scutellaria baicalensis Georgi, a plant of the Labiatae family. It is one of the commonly used Chinese medicinal materials recorded in the Chinese Pharmacopoeia. Scutellaria baicalensis is a typical representative plant of flavonoids, and the flavonoids contained in it account for more than 90% of the total ingredients. Mainly: baicalin, wogonin-7-O-glucuronide, oroxylin A-7-O-glucuronide and their aglycones. [0003] Modern pharmacological studies have shown that: Scutellaria baicalensis extract and its chemical components have various physiological activities, such as anti-inflammation, anti-virus, anti-cancer, anti-thrombosis and prevention of diabetic complications. The active ingredients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08C07H17/07
Inventor 张永煜邱明丰贾伟张玉峰张爱英
Owner SHANGHAI JIAO TONG UNIV
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