Biodegradable temperature-sensitive hydrogel and method for preparing same

Abstract

The invention discloses a biodegradable temperature-sensitive hydrogel and method for preparing same which consists of, preparing microporous konjak gluglucosan aqueous gel, preparing refined konjaku flour, dissolving in distilled water, agitating, charging inorganic solvent, adjusting pH, carrying out crossbridging under a controlled temperature and time, water scrubbing the product yield, repeated frost thawing, freeze-drying, then swelling the konjak gluglucosan gel into the aqueous solution of N-isopropyl acrylamide, cross linking agent, and initiating agent, carrying out polymerization under a controlled temperature and time, and water scrubbing the obtained outcome yield.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, more specifically to a biodegradable temperature-sensitive hydrogel, and also to a preparation method of the hydrogel, which is made of konjac glucomannan thermal alkali crosslinking, freeze-thawing treatment The resulting gel is an interpenetrating polymer network composed of poly-N-isopropylacrylamide. Background technique [0002] Polymer hydrogel is a body-shaped network of hydrophilic polymers that can swell in water and retain a large amount of water without dissolving. The many uses of hydrogels in the fields of biochemistry, medicine, agriculture, and daily chemical industry have aroused the general attention of scientists. Poly(N-isopropylacrylamide) hydrogel is a widely used synthetic polymer material with temperature sensitivity, but its non-biodegradability limits its application in biomedicine. [0003] As a natural polymer polysaccharide, ko...

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Problems solved by technology

[0005] However, the preparation of konjac glucomannan and temperature-sensitive polymer interpenetrating network hydrogel has not been reported