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Glossy ganoderma spore oil fat emulsion

A technology of Ganoderma lucidum spore oil and fat emulsion is applied in the directions of emulsion delivery, medical preparations containing active ingredients, unknown raw materials, etc. Simple, fully absorbed effect

Active Publication Date: 2005-05-18
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is an oral agent, which can be absorbed through the gastrointestinal tract after taking it, and cannot directly enter the blood of the human body. At present, there are no literature reports and products of Ganoderma lucidum spore oil injection dosage form.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Weighing: 12g of lecithin, 50g of soybean oil, 50g of Ganoderma lucidum spore oil, provided by Guangzhou Hanfang Modern Chinese Medicine Research and Development Co., Ltd., containing 30% of total triterpenoids, 15g of glycerin, 900ml of sterilized water for injection; finally obtained Ganoderma lucidum spore oil Fat emulsion 1000ml.

[0095] Preparation method: Add emulsifier (lecithin) to fatty oil (soybean oil) and Ganoderma lucidum spore oil under nitrogen gas, mash at high speed until lecithin is completely dissolved; disperse and emulsify in constant temperature water bath at 50°C and high speed at 12000rpm Under certain conditions, slowly add the oil phase into the glycerin aqueous solution until the mixture is uniform; adjust the pH to 7.0 with sodium hydroxide; immediately put the prepared colostrum into the homogenizer, adjust the homogenization pressure to 60Mpa, and the homogenization times to 8 Second, the homogenization temperature is 60°C. After homogeniz...

Embodiment 2

[0097] Weighing: 12g of lecithin, 50g of soybean oil, 50g of Ganoderma lucidum spore oil, provided by Guangzhou Hanfang Modern Chinese Medicine Research and Development Co., Ltd., containing 30% of total triterpenoids, 15g of glycerin, 900ml of sterilized water for injection; finally obtained Ganoderma lucidum spore oil Fat emulsion 1000ml.

[0098] Preparation method: Add lecithin to the oil phase under the condition of nitrogen gas, mash at high speed until the lecithin is completely dissolved; heat the oil phase and water phase to 60°C under constant temperature; mix the oil phase and glycerin aqueous solution by The ratio of 1:9 and the flow rate of 6ml / min are injected into the high-pressure homogenizer, and the homogenization pressure is adjusted to 60MPa, the number of homogenization is 12 times, and the homogenization temperature is 50°C. After repeated homogenization, the milk droplet size is suitable; adjust with sodium hydroxide pH to 7.0; filter with a microporous ...

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PUM

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Abstract

The present invention relates to tumor treating medicine, and is a kind of fat emulsion with spore oil extracted from glossy ganoderma as one Chinese medicinal material. The medicine contains glossy ganoderma spore oil 2.0-8.0 g, fatty oil 3.0-18.0 g, emulsifier 0.8-10 g, and isosmotic agent 0.5-6.0 g except injection water in each 100 ml. The medicine has the antitumor effect of glossy ganoderma spore oil and the nutrients replenishing effect of the fatty oil, and is suitable for salvage of serious tumor patient and post-operational nourishing. It may be used in arterial injection and intravenous injection to result in fast acting.

Description

technical field [0001] The invention relates to a medicine for treating tumors, in particular to a fat emulsion mainly composed of spore oil extracted from the traditional Chinese medicine Ganoderma lucidum. Background technique [0002] Since the 1980s, Japan has begun to conduct basic research on the anti-tumor aspect of Ganoderma lucidum; in the 1990s, the United States, Japan and other countries have applied Ganoderma lucidum to the clinic for the treatment of cancer and AIDS (AIDS), and have received international research. wide attention of scholars. The main active ingredients of Ganoderma lucidum include triterpenes, polysaccharides, ganoderma acid, nucleosides, etc.; ganoderma acid has strong pharmacological activity and can poison and kill tumor cells; triterpenes and polysaccharides can destroy the telomeres of cancer cells enzyme, the growth of the tumor is controlled and gradually shrinks. Ganoderma lucidum spore oil is extracted from the spore powder of the t...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61P35/00
Inventor 刘菊妍陈路林马芳励庞胜凤葛发欢吴德玄
Owner GUANGZHOU HANFANG PHARMA
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