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Volatile general anesthetic drug- propofol intravenous intralipid

A technology of fat emulsion and propofol emulsion, which is applied in the direction of anesthetics, oil/fat/wax non-active ingredients, pharmaceutical formulations, etc., can solve problems such as difficulty in adjusting the depth of general anesthesia, increasing the cost of general anesthesia, and affecting human liver and kidney functions. To achieve the effect of facilitating the depth of general anesthesia, reducing the residual lung capacity, and adjusting the depth of general anesthesia

Inactive Publication Date: 2005-07-06
刘进 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing inhaled general anesthetics need to be used through a special anesthesia machine and equipped with an inhaled general anesthetic volatilizer. The cost of anesthesia and medical expenses are high, and due to the influence of the breathing circuit and lung function residual capacity, the controllability of inhalation general anesthesia is poor, the induction speed is slow, and the amount of inhalation general anesthesia is insufficient; while the existing intravenous anesthesia General anesthetics need to circulate in the body with the veins and participate in the metabolism in the body when used, so the controllability of the existing intravenous general anesthetics is poor, which has a great impact on human liver and kidney functions, and it is difficult to adjust the depth of general anesthesia; As mentioned, the existing general anesthetics all need to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach      Embodiment 1

[0021] The specific embodiment Embodiment one, vortex oscillation method:

[0022] This method needs to pay attention to the airtightness of the container during the preparation process.

[0023] ①Take a 20ml glass ampoule and sterilize it by autoclaving for later use;

[0024] ②Precisely add 2g of refined soybean oil for injection, 0.24g of refined lecithin for injection, 0.45g of glycerin and 0.45g of glucose into the glass ampoule;

[0025] ③ Add appropriate amount of water for injection and shake well to get 20ml fat emulsion;

[0026] ④ Add 200 mg of propofol accurately to the above glass ampoule;

[0027] ⑤ Use an airtight glass syringe with a Teflon-coated tee to draw the liquid inhalation anesthetic isoflurane;

[0028] ⑥Weigh with an electronic scale, weigh out 0.6ml of liquid isoflurane,

[0029] ⑦Add 0.6ml of liquid isoflurane anesthetic into the above glass ampoule;

[0030] ⑧Melt-seal the above-mentioned glass ampoules;

[0031] ⑨ Place the melted glass ampo...

Embodiment 2

[0032] Embodiment two, magnetic stirring method

[0033] This method needs to pay attention to the airtightness of the container during the preparation process.

[0034] ①Take a 100ml glass volumetric flask and sterilize it by autoclaving for later use;

[0035] ②Precisely add 20g of refined soybean oil for injection, 1.2g of refined lecithin for injection, 2.0g of glycerol and 2.0g of glucose into the volumetric flask;

[0036] ③ Add appropriate amount of water for injection and shake well to get 100ml fat emulsion;

[0037] ④ Add 500 mg of propofol accurately to the above-mentioned volumetric flask;

[0038] ⑤ Use an airtight glass syringe with a Teflon-coated tee to draw the liquid inhalation anesthetic isoflurane;

[0039] ⑥Weigh with an electronic scale, weigh out 6.0ml of liquid isoflurane,

[0040] ⑦Add 6.0ml liquid isoflurane anesthetic into the above volumetric flask;

[0041] ⑧ Seal the volumetric flask above;

[0042] ⑨ Place the sealed glass ampoul...

Embodiment 3

[0043] Embodiment three, shear mixing method

[0044] This method needs to pay attention to the airtightness of the container during the preparation process.

[0045] ①Take a 2000ml glass Erlenmeyer flask and sterilize it by autoclaving for later use;

[0046] ②Precisely add 200g of refined soybean oil for injection, 24g of refined lecithin for injection, 45g of glycerol and 40g of glucose into the Erlenmeyer flask;

[0047] ③ Add appropriate amount of water for injection and shake well to get 2000ml fat emulsion;

[0048] ④ Add 20g of propofol accurately in the above-mentioned Erlenmeyer flask;

[0049] ⑤ Use an airtight glass syringe with a Teflon-coated tee to draw the liquid inhalation anesthetic isoflurane;

[0050] ⑥Weigh with an electronic scale, weigh out 60ml of liquid isoflurane,

[0051] ⑦Add 60ml of liquid isoflurane anesthetic into the above conical flask;

[0052] 8. Seal the above-mentioned Erlenmeyer flask;

[0053] ⑨Place the sealed glass a...

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PUM

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Abstract

Disclosed is a Propofol emulsion and its preparing method, which comprises intralipid, volatile general anesthetic and venous general anesthetic propofol of formulation concentration, the medicine can rapidly deepen general anesthesia and has the advantages of fast anaesthetic speed, less toxic and side effects, and extracorporeal circulation application.

Description

technical field [0001] The present invention relates to a kind of intravenous general anesthetic, i.e. volatile general anesthetic-propofol emulsion and preparation method thereof, in particular to a method of dissolving volatile general anesthetic and intravenous general anesthetic propofol together in fat A drug that is given in an emulsion and given intravenously to produce a general anesthetic. Background technique [0002] At present, there are generally two kinds of general anesthetics used in surgery in the medical field, namely inhalation general anesthetics and intravenous general anesthetics. Inhalation general anesthetics can be subdivided into volatile general anesthetics and gaseous general anesthetics. The existing inhaled general anesthetics need to be used through a special anesthesia machine and equipped with an inhaled general anesthetic volatilizer. The cost of anesthesia and medical expenses are high, and due to the influence of the breathing circuit an...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/08A61K47/24A61K47/44A61P23/02
Inventor 刘进张文胜罗南富
Owner 刘进
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