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Cubic liquid crystalline compositions and methods for their preparation

A cubic and compound technology, applied in the field of cubic liquid crystal composition and its preparation

Inactive Publication Date: 2005-07-13
CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no method to form cubic liquid crystal particles from dry powder precursors, all existing fragmentation and precursor processing utilize a relatively large proportion of liquid

Method used

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  • Cubic liquid crystalline compositions and methods for their preparation
  • Cubic liquid crystalline compositions and methods for their preparation
  • Cubic liquid crystalline compositions and methods for their preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Example 1 - Starch - Encapsulated Glyceryl Monooleate Powder

[0118] Use a Yamato Pulvis Basic spray drying unit (see figure 1 ) to produce powder. A dual flow nozzle with a liquid aperture of 0.040 inch (0.1 cm) and an air aperture of 0.1 inch (0.25 cm) was inserted into the top of the Yamato Pulvis spray dryer body. The body of the spray dryer consists of a drying chamber and a cyclone collector at the air outlet. A spray dryer is configured to flow heated drying air down through a nozzle. The heated dry air was set at 200°C. Sonicate the liquid crystal material with a sonicator. The feed was stirred at 25°C with a stir bar.

[0119] A spray-dried mixture of glyceryl monooleate (10% w / w), water (60%) and HI-CAP starch (30%) produced a first dry powder precursor. The resulting powder contained 25% glycerol monooleate and 75% starch, assuming all added water was removed. Subsequent measurements showed 4% to 10% moisture in the dried powder. After hydration of g...

Embodiment 2

[0122] Embodiment 2-starch-glycerol monooleate-hydrotrope powder

[0123]It has been found that adding a sufficient amount of hydrotrope to an aqueous glyceryl monooleate system produces low viscosity precursors which are easy to handle. The present invention improves upon these techniques to provide a method for more facile production of spray-dried cube precursors. The use of hydrotropes mimics the desired properties of active loaded systems, since many useful actives are also hydrotropes. Instead of ethanol, sodium p-toluenesulfonate (STS) was chosen because of its high melting point. In the case of starch-monooleate-water, use a mixture of glycerol monooleate (8% w / w), STS (8%), starch (24%) and water (60%) to form an easy pump A flowable liquid is supplied and maintained homogeneous by stirring to prepare a powder. The mixture was pumped through the liquid side of the two-fluid nebulizer at 6 mL / min, adjusting the pumping rate slightly to maintain the temperature of th...

Embodiment 3

[0125] Example 3 - Encapsulation of Active Ingredient (Fatty Acid Solution) in Powder

[0126] Powders are produced by spray drying liquid solutions. A liquid solution was prepared at 70°C from a premix of 67% water and 33% starch. A second solution of a mixture of 90% glycerol monooleate and 10% fatty acid (20% omega-3, 80% triglyceride oil) was prepared at 60°C. The oil solution was added to the starch-water solution to form A mixture of 9% Glyceryl Monooleate, 30% Starch, 60% Water and 1% Fatty Acid. The system was mixed using a high shear mixing system and maintained above 90°C. The mixture was pumped through the liquid side of the two-fluid nebulizer at a rate of 8 mL / min, adjusting the flow rate slightly to maintain the outlet air temperature of the system at 90°C-100°C. The liquid feed was atomized with air at a pressure of 42.6 psi (293.5 kPa). After drying, the powder had a composition of a mixture of 22.5% glyceryl monooleate, 75% starch and 2.5% fatty acid.

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Abstract

The present invention relates to a dry powder cubic gel precursor comprising an encapsulating compound, an amphiphile capable of forming a cubic liquid crystalline phase and optionally a solvent. Encapsulating compound (A), amphiphile (B) and optional solvent (C) exist in relative mass fractions, the relationship is 1.0=a+b+c, where a is the mass fraction of A and b is the mass of B Score, c is the quality score of C. In addition, 1.0>a>0, 1.0>b>0, 1.0>c>0, and a, b, and c are not in the cubic liquid crystal phase region on the phase diagram representing the phase behavior of A, B, and C.

Description

[0001] Cross References to Related Patents [0002] This application claims priority to the following pending and commonly owned U.S. Provisional Application: Provisional Application Serial No. 60 / 269,953, Docket No. 8423P, entitled "Cubic Liquid Crystal Compositions and Methods of Making Same"; in the name of Patrick T. Spicer Submitted on February 20, 2001. field of invention [0003] The present invention relates to the preparation of powders capable of forming cubic liquid crystal particles by hydration. Background of the invention [0004] Materials that can facilitate the targeted delivery of active substances through controlled release are highly valuable. Ideally, the delivery device would have high solubility for the active substance, a strong seal to avoid leakage during processing, storage, and use, be inexpensive, and be flexible for a variety of active substances and deliveries. method. Vesicles or liposomes (dispersed lamellar liquid crystal particles) are c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/04A01N25/30A01N37/34A01N41/02A01N43/70A01N43/76A01N47/12A01N47/24A01N57/16A61K9/127A61K9/14A61K9/16A61K45/00A61K47/02A61K47/10A61K47/12A61K47/14A61K47/16A61K47/18A61K47/20A61K47/26A61K47/34A61K47/36A61K47/40
CPCA61K9/1274A61K9/1617A61K9/1652
Inventor P·T·斯派塞W·B·斯莫尔二世M·L·林奇
Owner CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
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