Supermolecular intercalation-structure slow-release captopril and its preparing method

A slow-release and slow-release agent technology, which is applied in the field of supramolecular intercalation structure slow-release captopril and its assembly, to achieve the effect of suppressing odor, good slow-release effect, and good taste
CN1640395AInactive Publication Date: 2005-07-20BEIJING UNIV OF CHEM TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING UNIV OF CHEM TECH
Publication Date
2005-07-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a supermolecular intercalation structure slow-released captopril and its preparation method. Said invention uses anionic lamellar material LDH as main body, uses captopril as intercalation guest, and utilizes two soluble metal salts to make them into a mixed salt solution, then makes said mixed salt solution and alkali solution of captopril undergo the process of intercalation assembling treatment so as to obtain supermolecular structure CpI-LDHs. Said invention also provides its chemical formula. In said slow-released captopril preparation the mass percentage content of captopril is 20-50% and the mass percentage content of water is 5-20%, and its slow-released efficiency duration can be up to 0.5 hr-12hr.
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Description

Technical field:

[0001] The invention relates to a drug sustained-release agent and a preparation method thereof, in particular to a supramolecular intercalation structure sustained-release captopril and an assembly method thereof. Background technique:

[0002] At present, in response to the requirements of developing safe, efficient, economical and convenient sustained-release drugs, traditional drugs are used to create new dosage forms to realize the research and application of drug-controlled release systems with controllable drug release quantity, release time and release space. increasingly people's attention. The pharmaceutical sustained-release dosage forms developed based on traditional medicines can maintain a specific concentration at a point of action for a long time and have fewer side effects when administered, so they have the following advantages: (1) make the medicine release slowly and prolong the lasting effect; 2) Reduce toxicity; (3) Reduce side effects...

Claims

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