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Rhizome Anemarrhenae use of medicine preparation for treating or preventing diabetes mellitus

A technology of total saponins and diabetes, applied in the application field of timosaponins in the preparation of medicines for treating or preventing diabetes

Inactive Publication Date: 2005-10-12
刘志峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large number of studies have proved that total saponins of Anemarrhena are its main active ingredients. 17 kinds of monomeric saponins have been reported, but there is no information about total saponins of Anemarrhena inhibiting the activity of α-glucosidase, reducing postprandial blood sugar; promoting glucose metabolism and balancing blood sugar. , reports on drugs that lower blood lipids, promote insulin secretion, and maintain long-term blood sugar stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0006] Preparation example 1: Preparation of total timosaponins

[0007] Anemarrhena medicinal material is crushed into coarse powder, soaked in 70% ethanol for 4 hours, and then ultrasonically extracted three times at room temperature, the solvent multiple is 4:4:3, the extraction time is 3 hours each time, the extracts are combined and filtered, and the filtrate is concentrated to ethanol The content is about 30%, the AB-8 macroporous adsorption resin processed on the concentrated solution, the AB-8 macroporous adsorption resin after loading the sample is eluted with 30% ethanol for 2 column volumes, and 50% ethanol for 1 column volume Volume, 2 column volumes of 95% ethanol eluent, 95% ethanol eluent concentrated under reduced pressure to a thick paste, the thick paste was vacuum-dried to obtain total mother saponins; its total saponin content was 54%, and the content of smilagenin was 32.3 %.

preparation example 2

[0008] Preparation example 2: Preparation of total timosaponins

[0009] Anemarrhena medicinal material is crushed into coarse powder, soaked in 70% ethanol for 4 hours, and then ultrasonically extracted three times at room temperature, the solvent multiple is 4:4:3, the extraction time is 3 hours each time, the extracts are combined and filtered, and the filtrate is concentrated to ethanol The content is about 30%, the AB-8 macroporous adsorption resin processed on the concentrated solution, the AB-8 macroporous adsorption resin after loading the sample is eluted with 30% ethanol for 2 column volumes, and 50% ethanol for 1 column volume Volume, 95% ethanol elutes 2 column volumes, 95% ethanol eluent is concentrated under reduced pressure to a thick paste, and the thick paste is vacuum-dried to obtain the total saponins; its total saponin content is 84%, and the content of smilagenin is 52.3 %.

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Abstract

The invention provides Rhizome Anemarrhenae use of medicine preparation for treating or preventing diabetes mellitus. Specifically, the Rhizome Anemarrhenae inhibits Alpha-glucosidase, reduces the blood sugar after dinner, promotes the glucose metabolism, balances the blood sugar, reduces the blood fat, advances the insulin secretion and keeps the blood sugar stability.

Description

technical field [0001] The invention relates to a new medical application of total timosaponins, in particular to the application of total timosaponins in the preparation of medicines for treating or preventing diabetes. Background technique [0002] Anemarrhena is the dried rhizome of Anemarrhena asphodeloides Bge. in the liliaceae family. A large number of studies have proved that total saponins of Anemarrhena are its main active ingredients. 17 kinds of monomeric saponins have been reported, but there is no information about total saponins of Anemarrhena inhibiting the activity of α-glucosidase, reducing postprandial blood sugar; promoting glucose metabolism and balancing blood sugar. , Lower blood lipids, promote insulin secretion, and maintain long-term stable blood sugar drug reports. Contents of the invention [0003] The invention provides the application of total timosaponin in the preparation of medicine for treating or preventing diabetes. [0004] The inventi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P3/10
Inventor 刘志峰李春梅雷庆忠李大磊李慎军
Owner 刘志峰
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