Tromethamine gel form medicinal composition

A technology of ketorolac trometamol and its composition, which is applied in the direction of drug combination, drug delivery, antipyretic, etc., can solve the problem that the analgesic effect of the mouse hot plate is not obvious, and achieve the purpose of avoiding gastrointestinal stimulation and Other side effects, good water solubility, no allergic reaction effect

Inactive Publication Date: 2006-01-04
刘继东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ketorolac tromethamine topical gel has a significant inhibitory effect on carrageenan-induced paw swelling in rats; it has a significant inhibitory effect on the formation of cotton ball granuloma in rats; it can make the pain response caused by subcutaneous injection of formaldehyde Significantly relieved, but the analgesic effect of mouse hot plate test was not obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Ketorolac Tromethamine 5.0g

[0025] Carbomer 1.0g

[0026] Azone 2.0g

[0027] Borax 3.0g

[0028] Propylene glycol 5.0g

[0029] Benzalkonium Chloride 0.05g

[0030] Appropriate amount of water

[0031] Made into 1000g

[0032] Preparation Process:

[0033] 1. Preparation of carbomer gel After carbomer is soaked and swollen with water, 1% sol is made; borax solution (1%) is made by dissolving borax in hot water; the pH value of carbomer sol is adjusted with borax solution to 6.0±0.2 to make the carbomer gel transparent, add azone solution dissolved in propylene glycol, stir evenly, and set aside.

[0034] 2. Dissolve ketorolac trometamol and benzalkonium chloride in a small amount of water and set aside.

[0035] 3. Mix 1 and 2, stir evenly, add water to the full amount, continue to stir until uniform, and then get the gel.

Embodiment 2

[0037] Ketorolac Tromethamine 10.0g

[0038] Carbomer 3.0g

[0039] Azone 5.0g

[0040] Borax 5.0g

[0041] Propylene glycol 8.0g

[0042] Benzalkonium Chloride 0.08g

[0043] Appropriate amount of water

[0044] Made into 1000g

[0045] According to above-mentioned prescription, operate in the same way as Example 1, promptly get gel.

Embodiment 3

[0047] Ketorolac Tromethamine 10.0g

[0048] Carbomer 5.0g

[0049] Azone 10.0g

[0050] Borax 8.0g

[0051] Propylene glycol 10.0g

[0052] Benzalkonium Chloride 0.1g

[0053] Appropriate amount of water

[0054] Made into 1000g

[0055] According to above-mentioned prescription, operate in the same way as Example 1, promptly get gel.

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PUM

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Abstract

The present invention relates to tromethamine gel with tromethamine as effective non-steroid medicine component for relieving pain and diminishing inflammation caused by surgical operation, fracture, strain, cancer, etc. through skin, mucous membrane or other local application, and aims at raising the long term stability, raising the bioavailability of the medicine component, reducing stimulation and raising the curative effect and medicine applying safety. The final medicine composition contains tromethamine 0.5-2.0 wt%, gel matrix 0.1-1.0 wt%, transdermal absorbent 0.2-2.0 wt%, humectant 0.2-2.0 wt%, and pH buffering agent 0.3-1.5 wt%. It is preparation through convenient gel preparing process.

Description

[technical field] [0001] The invention relates to a gel-type composition containing non-steroidal anti-inflammatory drug ketorolac tromethamine, which is administered locally through the skin, mucous membrane, etc., and is used for moderate and severe pain such as post-operation, fracture, and sprain , toothache and cancer pain and other analgesic and anti-inflammatory treatments have good results. [Background technique] [0002] Ketorolac tromethamine is a therapeutic drug for skin diseases since the late 1980s. Since 1992, the U.S. FDA has successively approved Syntex’s ketorolac tromethamine raw materials, tablets, injections, and eye drops. These products have been listed in Belgium, France, Germany, Spain, India and other countries one after another. So far at home and abroad, there are no reports on the production and use of ketorolac tromethamine topical gel. Ketorolac tromethamine is a synthetic prostaglandin inhibitor with stronger systemic analgesic effect. Becau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61K9/00A61P29/00A61P25/04A61P19/08A61P1/02
Inventor 刘继东
Owner 刘继东
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