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Thrombus eliminating, channel activating soft capsule and its preparation method

A technology for eliminating blood clots, dredging collaterals, and soft capsules, which can be used in capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients. It can solve problems such as easy escape of volatile components, difficulty in controlling the difference in filling volume, and bad smell of drugs.

Inactive Publication Date: 2006-01-18
BEIJING LABWORLD BIO MEDICINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main defects in the prior art are: firstly, the medicine in the hard capsule is slowly absorbed by the human body, and the medicine is slow to take effect; secondly, the medicine in the hard capsule is easy to emit bitter taste and bad smell, which is not easy for patients to accept; thirdly, it is made of traditional Chinese medicine extract. It is difficult to control the difference in the amount of concentrated hard capsule medicine; finally, the hard capsule medicine has poor sealing performance, and the volatile components in the medicine are easy to escape, resulting in a decrease in the active ingredients and cannot be stored for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 4 parts of Rhizoma Chuanxiong, 3 parts of Salvia, 6 parts of Astragalus, 2 parts of Alisma, 1 part of Sophora japonica, 2 parts of Guizhi, 2 parts of Curcuma, 1 part of Muxiang, and 2 parts of Hawthorn, add water to decoct twice, the first time The first decoction is 1.5 hours, and the amount of water added is 10 times. The second decoction is 1.5 hours, and the amount of water is 8 times. A part of notoginseng fine powder is dried and crushed to more than 100 mesh to obtain the extract powder.

Embodiment 2

[0034] Take 4 parts of Rhizoma Chuanxiong, 3 parts of Salvia, 6 parts of Astragalus, 2 parts of Alisma, 1 part of Sophora japonica, 2 parts of Guizhi, 2 parts of Curcuma, 1 part of Muxiang, and 2 parts of Hawthorn, add water and decoct 3 times. For the first decoction for 1.5 hours, add 10 times the amount of water; for the second decoction for 1.5 hours, add 8 times the amount of water; Concentrate to 70°C to measure the relative density of 1.17-1.19, add 2 parts of notoginseng fine powder to dry, grind to 100 mesh or more, and obtain the extract powder. Mix the extract powder, PEG600, glycerol, and PEG6000, add 0.08 parts of borneol and pass through a colloid mill to mix evenly to obtain the content, and prepare soft capsules by pressing method. The soft capsules are cured and dried by cold wind, and the pills are washed with an appropriate solvent Finally dry, that is.

Embodiment 3

[0036] Take 4 parts of Rhizoma Chuanxiong, 3 parts of Salvia, 6 parts of Astragalus, 2 parts of Alisma, 1 part of Sophora japonica, 2 parts of Guizhi, 2 parts of Curcuma, 1 part of Muxiang, and 2 parts of Hawthorn, add water and decoct 3 times. For the first decoction for 1.5 hours, add 10 times the amount of water; for the second decoction for 1.5 hours, add 8 times the amount of water; Concentrate to 70°C to measure the relative density of 1.17-1.19, add 2 parts of notoginseng fine powder to dry, grind to 100 mesh or more, and obtain the extract powder. Mix the extract powder, PEG400, propylene glycol, and PEG4000, add 0.08 parts of borneol and pass through a colloid mill to mix evenly to obtain the contents. The soft capsules are prepared by pressing. The soft capsules are cured by cold air and dried. The pills are washed with an appropriate solvent and finally dried. , that is.

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PUM

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Abstract

The invention discloses a soft capsule for thrombus eliminating and channel activating, wherein the content of the soft capsule comprises 10-70 wt% of medicinal powder and 30-90 wt% of auxiliary material, the medicinal powder comprises borneol, Ligusticum wallichii, root of red rooted saliva, astragalus root, oriental water plantain rhizome, notoginseng, pagodatree flower, cassia twig, curcuma aromatica, banksia rose and haw thorn.

Description

technical field [0001] The invention relates to a traditional Chinese medicine and a preparation process thereof, in particular to a traditional Chinese medicine soft capsule and a preparation process thereof. Background technique [0002] Xiaoshuan Tongluo Capsule is a pure Chinese medicine preparation extracted and refined by scientific methods from 11 traditional Chinese medicines of Chuanxiong, Danshen, Astragalus, Alisma, Panax notoginseng, Sophora japonica, Guizhi, turmeric, woody fragrance, borneol, and hawthorn. It has the effects of promoting blood circulation and removing blood stasis, warming meridians and dredging collaterals. It is used for stroke caused by blood stasis blocking collaterals. The symptoms include sluggish expression, slurred speech, cold hands and feet, and limb pain. For ischemic stroke and hyperlipidemia, see the above symptoms. [0003] The main defects in the prior art are: firstly, the medicine in the hard capsule is slowly absorbed by the ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/48A61P7/02A61P9/10
Inventor 宛六一
Owner BEIJING LABWORLD BIO MEDICINE TECH
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