Novel drug administering route of ginseng stem and leave general saponin and its preparation process and new indications

A technology for ginseng stem, leaf and glycoside injection, which is applied in the new administration route and preparation process of ginseng stem and leaf total saponins injection, and new indication fields, and can solve problems such as slow absorption, secondary infection, and limited clinical application

Inactive Publication Date: 2006-02-08
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in terms of clinical application, ginseng stem and leaf saponins injection (GSL) adopts the intramuscular injection method, which is absorbed through the tissue at a slower rate and with a smaller dose, which not only increases the pain of the patient, but also causes local induration and even swelling of the injection site. Pain, secondary infection, frequent injections can easily lead to "Gluteal Muscle Contracture"
This medication method obviously limits its clinical application
Therefore, in response to this problem, we have developed an intravenous route of administration, which overcomes the shortcomings of slow absorption and long onset time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation method of injection of the present invention:

[0042] prescription:

[0043] Total saponins from ginseng stems and leaves 6.7g

[0044]F-68 3g

[0045] Makes 1000ml

[0046] Preparation:

[0047] Take the total saponins of ginseng stems and leaves, add water for injection, heat and dissolve on a water bath, let cool, filter, adjust the pH value of the filtrate to 6.5-6.8 with 0.1M sodium hydroxide solution, add 3g F-68 to dissolve, add water for injection to 1000ml , filtered through a microporous membrane (0.22 μm) until clear, potted, and sterilized at 100°C for 30 minutes.

Embodiment 2

[0049] The preparation method of freeze-dried powder of the present invention:

[0050] prescription:

[0051] Total saponins from ginseng stems and leaves 13.3g

[0052] F-68 3g

[0053] Dextran-40 30g

[0054] Makes 1000ml

[0055] Preparation:

[0056] Take the total saponins of ginseng stems and leaves, add water for injection, heat and dissolve on a water bath, let cool, filter, add dextran-40 to the filtrate, stir well, adjust the pH value to 6.5-6.8 with 0.1M sodium hydroxide solution, After adding F-68 to dissolve, add water for injection to 1000ml, filter through a microporous membrane (0.22μm) until clear, and fill the filtrate into 15ml vials, 5ml per bottle. Then place it in a freeze-drying box to pre-freeze for 3 to 5 hours and then vacuumize. After freeze-drying for 24 hours, press the plug and roll the cap to obtain the product.

Embodiment 3

[0058] The preparation method of sterile powder of the present invention:

[0059] prescription:

[0060] Total saponins from ginseng stems and leaves 56.5g

[0061] F-68 10g

[0062] Mannitol 750g

[0063] Makes 1000 bottles

[0064] Preparation:

[0065] Take the total saponins of ginseng stems and leaves, add water for injection, heat and dissolve on a water bath, let cool, filter, add mannitol to the filtrate, stir evenly, adjust the pH value of the filtrate to 6.5-6.8 with 0.1M sodium hydroxide solution, add F-68 After dissolving, add water for injection to the specified amount, filter through a microporous membrane (0.22 μm) until clear, and spray the filtrate with a spray drying tower under sterile conditions to make a sterile powder, which is then packaged.

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PUM

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Abstract

The invention relates to a traditional Chinese medicinal injection for treating coronary disease, climacteric metancholia, myocardial ischemia, hypoxic encephalopathy and hyperlipoidemia. The invention also discloses its preparing process, new route of administration and new indication errors. The injection is prepared from total saponins of ginseng leaves as raw material, as well as concentrated solution for injection, freeze-dried powder, 5% glucose and 0.9% sodium chloride.

Description

Technical field: [0001] The invention relates to a new administration route, a preparation process, and a new indication of ginseng stem and leaf total saponins injection. technical background: [0002] Cardiovascular and cerebrovascular diseases, such as coronary heart disease, are the main cause of human disease and death, accounting for one-third of the total mortality rate, and its mortality rate has surpassed that of cancer in China. Moreover, with the improvement of living standards, the number of patients is increasing, which poses a huge threat to the lives of patients. At the same time, patients often need to take medicine for a long time or for a lifetime, which seriously affects the quality of life and imposes a heavy burden on patients' families and even the whole society. Menopausal syndrome mostly occurs between the ages of 45 and 55, especially in women. [0003] At present, there are many Chinese and Western medicines for the treatment of coronary heart dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/08A61K9/14A61K9/19A61P9/10A61P9/04A61P3/06A61P35/00
Inventor 刘露
Owner FUKANGREN BIO PHARMA
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