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Mucous membrane absorption ingestion type medicinal composition for drawing out interferon, and preparation

A composition and interferon technology, applied in the directions of drug combination, drug delivery, medical preparations containing active ingredients, etc., can solve problems such as unsatisfactory effects, and achieve the effect of preventing and treating viral infections

Inactive Publication Date: 2006-04-19
秦卫华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the results of the study show that the effect of nasal administration of polymyocytes alone is not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The formula of the mucous membrane absorption and uptake type interferon-inducing medicinal composition of the present invention:

[0030] Recipe 1 3mol Chitosan 6000 Daltons

[0031] 1 mol of polymyocytes 200,000 Daltons

[0032] Recipe 2 2mol chitosan 10,000 Daltons

[0033] 1 mol of polymyocytes 300,000 Daltons

[0034] 1000 units Kanamycin

[0035] Recipe 3 1mol chitosan 100,000 Daltons

[0036] 1 mol of polymyocytes 50,000 daltons

[0037] 1000 units Kanamycin

[0038] Recipe 4 10mol chitosan 500,000 Daltons

[0039] 1 mol of polymyocytes 400,000 Daltons

[0040] Recipe 5 1mol chitosan 600,000 Daltons

[0041] 10mol polyinocytes 20,000 Daltons

[0042] Recipe 6 2 grams of polylysine 500,000

[0043] 3 grams of polymyocytes 100,000 Daltons

[0044] Recipe 7 1g Polyarginine 10,000 Daltons

[0045] 3 grams of polymyocytes 100,000 Daltons

[0046] Recipe 8 1mol Chitosan 2000 Daltons

[0047] 1 ...

Embodiment 2

[0073] Embodiment 2 spray, solution type nasal drops

[0074] The spray and the solution type nasal drops of the present invention polysaccharide-polyinocytidine, chitosan-polyinocitate adopt following formula:

[0075] Recipe 1

[0076] Polymyocytes Molecular weight 100,000 Daltons 1mg

[0077] Chitosan molecular weight 10,000 daltons 10mg

[0078] Hydrochloric acid Adjust the pH value to 5.5

[0079] Purified water 100ml

[0080] Recipe 2

[0081] Polymyocytes Molecular weight 300,000 Daltons 1mg

[0082] Chitosan molecular weight 20,000 daltons 10mg

[0083] Hydrochloric acid to adjust the pH to 6

[0084] Purified water 100ml

[0085] Recipe 3

[0086] Polymyocytes Molecular weight 10,000 Daltons 10mg

[0087] Chitosan molecular weight 10,000 daltons 1mg

[0088] Hydrochloric acid Adjust the pH value to 5.5

[0089] Purified water 100ml

[0090] Recipe 4

[0091] Polymyocytes Molecular weight 30,000 Daltons 10mg

[0092] Chitosan Molecular weight 20,00...

Embodiment 3

[0101] Embodiment 3 powder mist

[0102] Chitosan-polymyocyte powder spray formula of the present invention is as follows:

[0103] Recipe 1

[0104] Polymyocytes Molecular weight 100,000-300,000 Daltons 1mg

[0105] Chitosan molecular weight 10,000 daltons 5mg

[0106] Microcrystalline Cellulose 10mg

[0107] Recipe 2

[0108] Polymyocytes Molecular weight 200,000 Daltons 1mg

[0109] Chitosan molecular weight 20,000 Daltons 5mg

[0110] Microcrystalline Cellulose 10mg

[0111] Recipe 3

[0112] Polymyocytes Molecular weight 300,000 Daltons 1mg

[0113] Chitosan molecular weight 20,000 Daltons 5mg

[0114] Microcrystalline Cellulose 10mg

[0115] Preparation

[0116] Vacuum-dry 100 ml of the pharmaceutical composition prepared in Step 3 of Example 1 to a constant weight, and pulverize it into a fine powder to prepare a mucosa-absorbable interferon-inducing powder.

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Abstract

A mucosa absorption type medicinal composition for inducing interferon contains the polymyocell or its derivative and one or more of the pharmacologically acceptable salts and the polycationic compound and one or more of the pharmacologically acceptable salts. Its preparation in the form of solution, aerosol, spray, or powder for inducing the immune system to generate interferon is also disclosed.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition for inducing interferon and the preparation form using the pharmaceutical composition, more specifically, the present invention relates to a kind of interferon that can be well absorbed and taken up by mucosal tissue, used for A pharmaceutical composition for inducing interferon and its preparation form. Background technique [0002] Interferon (IFN) has antiproliferative and antiviral effects. Double-stranded ribonucleic acid can be used as an inducer of human and animal α, β, γ and other models of interferon (J. Reticuloendothelial Society, 23, 299, 1978). Since both natural double-stranded RNA and synthetic double-stranded RNA have the functions of inducing IFN production and inducing natural killer (NK) cells, they can be used as vaccines. Representative double-stranded ribonucleic acid has polyinocytosis (PolyIC), polyinocytosis and polyadenuria. For example, US Patent No. 3,...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/785A61K9/08A61K9/12A61K9/72A61P43/00
Inventor 秦卫华
Owner 秦卫华
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