Method for extracting ferula feruloides medicinal composition

A kind of extraction method and technology of Astragalus polysaccharides, applied in the field of extraction of Astragalus polysaccharides medicinal composition

Inactive Publication Date: 2006-04-26
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, no patent reports have been found to extract guaiacol, 2,4-dihydroxyacetophenone sesquiterpene derivatives, and sesquiterpene derivatives of 2,4-dihydroxyacetophenone from Ferulicum ferulae using supercritical carbon dioxide extraction technology. Report on Terpene Derivatives and Sesquiterpene Coumarins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Weigh 330g of ferulae ferulae root, pulverize it, and add it to a supercritical carbon dioxide extractor. Firstly, use carbon dioxide for the first extraction. Extraction pressure: 15Mpa, extraction temperature: 50°C, extraction time: 3.5 hours, separation pressure: 4.0Mpa, separation temperature: 30°C, after the extraction is completed, collect the extract in the separator, and after drying, extract I is 13.9 grams, with an extraction rate of 4.2%. The main component of extract I is guaiacol. Matter I was left at room temperature for 7 days, then filtered to obtain guaiacol crystals;

[0016] Then the remaining slag is extracted for the second time with carbon dioxide and carrier ethanol (volume ratio 10:1), extraction pressure: 25MPa, extraction temperature: 50°C, separation pressure: 4.5MPa, separation temperature: 30°C, extraction time : 4 hours, after extraction, collect the extract in the separator, get extract 18.7g after decompression distillation ethanol, yield...

Embodiment 2

[0018] Weigh 350g of ferulae ferulae root, pulverize it, and add it to a supercritical carbon dioxide extractor. Firstly, use carbon dioxide for the first extraction. Extraction pressure: 10Mpa, extraction temperature: 40°C, extraction time: 3.5 hours, separation pressure: 3.0Mpa, separation temperature: 40°C, after the extraction is completed, collect the extract in the separator, and dry it to obtain 13.7 grams of the extract, with an extraction rate of 3.9%, wherein the main component of the extract I is guaiacol, the extract I After standing at room temperature for 7 days, filter to obtain guaiacol crystals;

[0019] Then the remaining slag is extracted for the second time with carbon dioxide and carrier ethanol (volume ratio 100:5), extraction pressure: 30MPa, extraction temperature: 40°C, separation pressure: 7.8MPa, separation temperature: 40°C, extraction time : 4 hours, after the extraction is complete, collect the extract in the separator, obtain extract 19.3g after ...

Embodiment 3

[0021] Take by weighing 342g of Ferulicum ferulae root, through pulverization, join in the supercritical carbon dioxide extractor, at first carry out the first extraction with carbon dioxide. Extraction pressure: 20MPa, extraction temperature: 45°C, extraction time: 4 hours, separation pressure: 4.0MPa, separation temperature: 30°C. After the extraction was completed, the extract in the separator was collected and dried to obtain 15.3 grams of the extract, with an extraction rate of 4.4%, wherein the main component of the extract I was guaiacol, and the extract I was placed at room temperature for 7 days before being filtered. Obtain guaiacol crystals;

[0022] Then the remaining slag is extracted for the second time with carbon dioxide and carrier acetone (volume ratio 100:5), extraction pressure: 40MPa, extraction temperature: 45°C, separation pressure: 4.5MPa, separation temperature: 35°C, extraction time : 4 hours, after extraction, collect the extract in the separator, g...

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Abstract

The invention relates to a process for extracting Ferula ferulaeoides medicinal composition through supercritical carbon dioxide extraction, wherein two positions with different medicinal use were separated from nonpolar or low polar compounds such as champacol and other terpenoids, and medium polarity or high polarity compounds such as 2,4-dihydroxyacetophenone sesquiterpene derivative, 2,4-dihydroxyphenyl propanone sesquiterpene derivative, and sesquiterpene coumarin.

Description

technical field [0001] The invention relates to an extraction method for extracting a medicinal composition from folk medicinal plant Ferula ferlaeoidis (Sted.) Korov. by means of supercritical carbon dioxide extraction technology. Background technique [0002] Multi-umbrella Ferulicum is also known as Naxiang Ferulic, Fragrant Ferulic, and Sanjiu Ferulic. Folks use the liquid or resinous substance secreted by its roots or rhizomes to treat digestive system diseases. It has the functions of stopping dysentery, eliminating accumulation, detoxification, Inflammation and other effects. [0003] There are about 150 species of ferulic plants distributed in the vast area from Central Asia to the Mediterranean. The medicinal uses of ferulic plants include: anti-spasmodic, treatment of asthma, detoxification, anti-coagulation, anti-fertility, anti-oxidation, etc., for digestion, blood The circulatory, nervous, and immune systems are all affected. [0004] Studie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61P1/12A61P1/14A61P29/00
Inventor 赵文军吴雪萍宋东伟向迎梅高林
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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