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Medicine containing cepharanthine

A technology of stephatrin and medicine, which is applied in the field of improving the dosage form of the original tablet, and can solve problems such as the unsatisfactory disintegration and dissolution performance of stephatrin tablets in vitro, and the influence of stephatrin tablets on bioavailability, etc. , to achieve the effect of good promotion and practical value, good clinical curative effect and fast absorption

Inactive Publication Date: 2006-05-17
袁继民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the in vitro disintegration and dissolution properties of stephatrin tablets are not ideal, and stephatrin is not soluble in water, the bioavailability of stephatrin tablets is affected to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Preparation of Stephania Soft Capsules

[0014] (1) Preparation of drug suspension: Weigh 20 g of patinol and 280 g of polyethylene glycol 400, stir in a material tank, and grind through a colloid mill for later use.

[0015] (2) Glue preparation: Weigh 1000 g of gelatin, 950 g of purified water, 350 g of glycerin, and 15 g of titanium dioxide for later use. Titanium dioxide, purified water, and glycerin are firstly mixed in a ratio of 1:1:1, and ground by a colloid mill for later use. Then put the remaining purified water, glycerin, and gelatin in a chemical glue tank, soak for 30 minutes, heat up, and stir occasionally. After the gelatin is dissolved, vacuumize for 30 minutes to remove air bubbles in the glue, pass through a 120-mesh sieve to remove impurities, and keep warm at 60°C spare.

[0016] (3) Pressed pills: Take the above-mentioned prepared medicine liquid and put it in the hopper of the pill press machine, adjust the thickness of the rubber and...

Embodiment 2

[0019] The polyethylene glycol 400 in Example 1 was replaced by peanut oil, and the others were basically unchanged to obtain soft capsule 2.

Embodiment 3

[0020] Example 3: Preparation of Stephaniacine Hard Capsules

[0021] Prescription: stephadin 20g

[0022] 180g powdered sugar

[0023] Magnesium Stearate Appropriate amount

[0024] Makes 1000 capsules

[0025] Preparation method: Mix rattan and sugar powder, pass through 80-mesh sieve and mix well, use 30% ethanol to make soft material, pass through 30-mesh sieve to granulate, dry at 60°C, add magnesium stearate, mix well, Pack into capsules, 0.2g per capsule. Get hard capsules.

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PUM

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Abstract

The present invention relates to five kinds of improved cepharanthine medicine preparation, including soft cepharanthine capsule, hard cepharanthine capsule, dispersed cepharanthine tablet, cepharanthine for injection and cepharanthine liquid for injection. These cepharanthine medicine preparations have the features of extracorporeal disintegration, complete absorption, high bioavailability and high clinical treating effect.

Description

(1) Technical field [0001] The invention relates to 5 new dosage forms of paternogenin, which belong to the improvement of the dosage forms of the original tablets. (2) Background technology [0002] Stephaniacine is an active ingredient that is extracted and isolated from Stephania genus plants and has the effect of increasing white blood cells. Stephania Tablets made of Stepherin have been widely used clinically to treat leukopenia caused by radiotherapy and chemotherapy. Due to the in vitro disintegration and dissolution properties of the stepherin tablets are not ideal, and the stepherin is not soluble in water, the bioavailability of the stepherin tablets is affected to a certain extent. (3) Contents of the invention [0003] In order to overcome the deficiencies of the following technologies, the present invention provides a new oral dosage form with excellent in vitro disintegration, dispersion and drug release performance, and an injection dosage form with fast ab...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61K9/08A61K9/20A61K9/48A61P7/00
Inventor 袁继民
Owner 袁继民
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