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Water-base magnetic liquid and producing method thereof

A magnetic liquid, water-based technology, applied in magnetic liquids, radioactive carriers, gene therapy, etc., can solve the problems of large particle hydrodynamic diameter, complex connection process, low surface potential, etc., and achieve good biocompatibility.

Inactive Publication Date: 2006-05-17
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the polysaccharide stabilizers currently used are dextran, chitosan, starch, etc., because there are only hydroxyl groups on the molecular chains of these polysaccharides, the force between them and the nanometer ferroferric oxide particles is small, and the modification effect Not ideal, the surface potential is low, the particle stability is poor, and the chemically active groups on the particle surface after modification are less, and the connection process with drugs, cells, proteins or genes is more complicated
In particular, the current preparation method makes this kind of water-based magnetic liquid have the disadvantages of too large particle hydrodynamic diameter, generally exceeding 300nm, thick outer coating layer, low saturation magnetization, or poor biocompatibility.

Method used

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  • Water-base magnetic liquid and producing method thereof
  • Water-base magnetic liquid and producing method thereof
  • Water-base magnetic liquid and producing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Take 9.6g FeCl 3 .6H 2 O, formulated as FeCl with a mass concentration of 60% 3solution, weighing 5g FeSO 4 .7H 2 O, formulated as FeSO with a mass concentration of 20% 4 solution, the two solutions are mixed to form an iron salt mixed solution, and the molar ratio of ferrous sulfate: ferric chloride=1:2. 20g of sodium alginate with a weight average molecular weight of 20,000 is dissolved in 100ml of concentrated ammonia of 25Wt% to form a mixed solution of sodium alginate and ammonia. The mass ratio to ferric oxide is 5:1. Mix the iron salt mixed solution and the sodium alginate ammonia mixed solution under stirring at 800 rpm, then react under stirring for 40 minutes, and the reaction temperature is stabilized at 90°C; Centrifuge the ferroferric oxide magnetic liquid to remove the precipitated large particles, ensure that the nano-ferric ferric oxide particles are uniform in size and dispersed in water stably, collect the supernatant as a stable water-based ferr...

Embodiment 2

[0038] Take 9.6g FeCl 3 .6H 2 O, formulated as FeCl with a mass concentration of 30% 3 solution, weighing 5g FeSO 4 .7H 2 O, formulated as FeSO with a mass concentration of 15% 4 solution, the rest of the steps are the same as in Example 1, and 50ml of magnetic liquid with an iron content of 3mg / ml can be obtained, and the saturation magnetization is about 0.5kA / m.

Embodiment 3

[0040] Take 9.6g FeCl 3 .6H 2 O, formulated as FeCl with a mass concentration of 45% 3 solution, weighing 5g FeSO 4 .7H 2 O, formulated as FeSO with a mass concentration of 30% 4 solution, the rest of the steps are the same as in Example 1, and 30ml of magnetic liquid with an iron content of 9mg / ml can be obtained, and the saturation magnetization is about 1.6kA / m.

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Abstract

A method for preparing water ¿C based magnetic liquid includes using carboxyl polysaccharide as stabilizer of magnetic liquid, applying chemical coprecipitation process to form water ¿C based magnetic liquid of magnetic iron oxide under stabilizer existence or applying chemical coprecipitation process to form nanoparticles of magnetic iron oxide first then carrying out surface modification to obtain water ¿C based magnetic liquid of magnetic iron oxide.

Description

technical field [0001] The invention relates to a water-based magnetic liquid and a preparation method thereof. technical background [0002] The so-called magnetic liquid refers to a stable colloidal system formed by highly dispersed nano-magnetic particles adsorbed with a stabilizer in a carrier liquid. It is mainly composed of nano magnetic particles, stabilizer and carrier liquid. At present, water-based magnetic liquids can be divided into three categories according to the types of stabilizers used: 1. Use water-soluble small organic molecules such as amino acids, citric acid, folic acid, etc. as chelating agents and stabilizers; 2. Use surface Active agents form a double-layer adsorption mode on the surface of nano-magnetic particles to prepare water-based magnetic liquids. The surfactants used include fatty acids, N-acyl amino acids, etc.; 3. Using polymers with hydrophilic groups as stabilizers, the stabilizers used Agents mainly polysaccharides, proteins, polyacry...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/44A61K48/00A61K49/08A61K51/02
Inventor 徐雪青沈辉许家瑞
Owner SUN YAT SEN UNIV
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