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Azasetron hydrochloride glucose injection formulation, and its preparing method and quality control technology

A technology of azasetron hydrochloride and glucose injection, which is applied in the field of preparation method and quality control, antiemetic preparations, and can solve the problems of easy drug resistance, increased drug toxicity, and affecting the quality of life of patients

Inactive Publication Date: 2006-05-24
余世春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The selectivity of anti-cancer drugs to cancer cells and normal human cells is not much different, so the adverse reactions during the application process are extensive and serious, the most common are nausea and vomiting gastrointestinal reactions, highly emetogenic radiotherapy and chemotherapy drugs The resulting nausea and vomiting can not only cause dehydration, electrolyte imbalance, delay the washout of radiotherapy and chemotherapy and increase the toxicity of drugs, but also affect the quality of life of patients
In addition, easy drug resistance is also one of the problems in the treatment process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0095] Prescription 1:

[0096] Azasetron Hydrochloride 0.1g

[0097] Glucose 50g

[0098] Sodium bisulfite 20mg

[0099] Add water for injection to 1000ml

[0100] Preparation Process

[0101] Weigh the prescribed amount of glucose, dissolve it in the full amount of 90°C water for injection, stir to fully dissolve the glucose, add 0.1% activated carbon for needles, keep stirring for 15 minutes, filter and decarbonize, and adjust the pH value to 3.5-4.5 , Determination of content, spare. Take another prescribed amount of azasetron hydrochloride and sodium bisulfite, avoid light, dissolve with 100ml of the above glucose solution, add 0.05% activated carbon for needles and stir for 15 minutes at room temperature, filter, decarbonize, measure the content of intermediates, and use Dilute the glucose solution to the required concentration, filter it through a 0.22 μm microporous membrane, measure the content and pH value, fill it into a 100ml infusion bottle after passing the ...

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Abstract

The present invention discloses an antiemetic ayasetron hydrochloride glucose injection preparation, its preparation method and quality control technique. Its composition includes ayasetron hydrochloride 0.1g, glucose 40-50g and sodium hydrogen sulfite 0-20mg. All the above-mentioned components are added into injection water, and dissolved to 1000ml so as to obtain the invented product. Said preparation is a fluid infusion type preparation, and can be used for clinical application.

Description

technical field [0001] The invention discloses a preparation, preparation method and quality control technology of an antiemetic, specifically a preparation, preparation method and quality control technology of azasetron hydrochloride glucose injection. Background technique [0002] Malignant tumor is a common and frequently-occurring disease that seriously threatens human health. It is a major scientific research topic in the field of medical science in all countries in the world. At present, there are no satisfactory prevention and control measures. The methods of treating malignant tumors are still surgical resection, radiotherapy and chemotherapy, and the latter is still an important method for clinical treatment. The selectivity of anti-cancer drugs to cancer cells and normal human cells is not much different, so the adverse reactions during the application process are extensive and serious, the most common are nausea and vomiting gastrointestinal reactions, highly emet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/536A61K9/08A61P1/08
Inventor 余世春
Owner 余世春
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