Tech. for extracting high purity chlorogenic acid from honeysuckle

An extraction process, chlorogenic acid technology, applied in the separation/purification of carboxylic acid esters, organic chemistry, etc., can solve the problems of unsatisfactory and low purity of chlorogenic acid

Inactive Publication Date: 2006-06-28
CANGYUAN PHARMA DEV FUZHOU
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Problems solved by technology

Even so, the purity of chlorogenic acid produced by the prior art is generally not high, as the purity of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: The process is as follows:

[0024] (1) Pretreatment of honeysuckle medicinal materials, removing impurities, mildew, cleaning, air-drying or sun-drying.

[0025] (2), add the oral grade drinking water of 15 times the weight of honeysuckle, add NaHSO 3 Make its concentration reach 1.5%, add a yield promoter to make its concentration reach 1‰, increase the temperature at 70∽90°C, pH 5∽6, stir for 2 hours at intervals, extract 3 times, and use the third mother liquor for the next batch of feeding.

[0026] (3), merge NO.1.2 times to extract the mother liquor, add Yaosheng 1+1 clarifying agent II-B or IV-B5 / 10,000, slowly add it to make its concentration reach 3 / 10,000, heat up 70∽90℃, PH5∽6 , stirring at intervals of 1.0 hours, and plate-and-frame pressure filtration to obtain a clear filtrate.

[0027] (4), return to pH 5.0, stir for 1.0 hours, filter by plate and frame, or add diatomaceous earth to assist in filtration to obtain a clear filtrate.

[0028] ...

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PUM

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Abstract

The invention relates to a honeysuckle high purity chlorogenic acid distilling technology. The technology includes four steps: adding NaHSO3, yield promoting agent and clarifier, sheet frame filter-press, passing macro hole adsorbing resin to gain concentrated solution, spraying and drying to gain taking orally chlorogenic acid; adding alcohol and depositing, adding water taking second clarifying process, taking active carbon process, pressure decreasing and concentrating, spraying and drying to gain honeysuckle distilling material; adding beta-CD into the clarified solution to take complex reaction, adding cyclohexanone decomplexing to gain concentrated chlorogenic acid, drying in vacuum could gain the chlorogenic acid that the content could be 90%; dissolving the concentrated solution by alcohol, using silica gel chromatography column to take section analysis, testing, combining the same section, decreasing pressure and drying, crystallizing, the chlorogenic acid that has the content over 95% would be gained, which was tested by HPLC method.

Description

technical field [0001] The invention relates to a method for extracting and purifying functional components of Chinese herbal medicine, in particular to a process for extracting high-purity chlorogenic acid from honeysuckle by extracting and purifying chlorogenic acid from honeysuckle. Background technique [0002] Domestic methods of extracting chlorogenic acid from honeysuckle generally include: water extraction lime milk method, water extraction method, water extraction alcohol precipitation method, dilute alcohol extraction method, lime sulfur method and other methods. The flocculation method is used to extract from honeysuckle flower. The research and application of chlorogenic acid are also reported in the literature; the purification methods of chlorogenic acid generally include: ethyl acetate method, n-butanol method, stone-sulfur method and macroporous resin methods, such as: patent application number: 01144170, The name of the invention is "the extraction and purif...

Claims

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Application Information

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IPC IPC(8): C07C67/48C07C69/732
Inventor 毕思彬周河龙罗文伟吴茂芝曾爱民王建平
Owner CANGYUAN PHARMA DEV FUZHOU
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