Cefixime oral disintegration tablet and its preparation method

A technology for oral disintegrating tablets and cefixime, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of increased production costs, increased manufacturing processes, etc., and achieves low cost and rapid onset of action. , the preparation method is simple

Active Publication Date: 2006-07-19
SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

The separate granulation method increases the manufactur

Method used

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Embodiment Construction

[0023]The present invention is described in further detail below in conjunction with embodiment. The cefixime orally disintegrating tablet of the present invention has the following components by weight: 10.0%-35.0% of cefixime, 0%-10.0% of microcrystalline cellulose, 0%-35.0% of lactose starch, and 35.0%-59.0% of mannitol %, croscarmellose sodium 4.0%~15.0%, copovidone 1.0%~5.0%, sodium lauryl sulfate 0.01%~1.0%, micropowder silica gel 0.01%~0.5%, flavoring and coloring Agent 0% ~ 3.0%.

[0024] The preferred weight ratio components are: cefixime 10.0%-30.0%, microcrystalline cellulose 5.0%-10.0%, lactose starch 0%-25.0%, mannitol 40.0%-59.0%, cross-linked carboxymethyl cellulose Sodium 4.5% to 15.0%, copovidone 1.0% to 4.0%, sodium lauryl sulfate 0.01% to 1.0%, micronized silica gel 0.01% to 0.5%, flavoring and coloring agents 0% to 3.0%.

[0025] Another preferred weight ratio component is: 10.0% to 25.0% of cefixime, 5.0% to 10.0% of microcrystalline cellulose, 0% to 25....

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Abstract

The invention discloses an orally disintegrating cefixime tablet and its preparation, wherein the ingredients include (by weight ratio): cefixime 10.0-35.0%, crystalline cellulose 0-10%, lactose starch 0-35%, mannitol 35.0-59%, cross-linked sodium carboxymethylcellulose 4.0-15.0%, Kollidon 1.0-5.0%, sodium dodecylsulfate 0.01-1.0%, and silica gel powder 0.01-0.5%, the preparing process comprises the following steps, mixing the medicinal materials homogeneously, charging water, ethanol or their mixture, granulating and drying, mixing homogeneously with miropowdered silica gel and tabletting.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a cefixime orally disintegrating tablet and an industrially applicable preparation method thereof. Background technique [0002] In recent years, with the deepening of theoretical research on drug delivery systems and the development of polymer material science, the research on drug delivery systems has been increasing from varieties to dosage forms. An orally disintegrating tablet is a tablet that disintegrates or dissolves quickly in the mouth. Usually the disintegration time is several seconds to tens of seconds, generally not more than 1 minute. Form a suspension or solution in the mouth without additional water. Orally disintegrating tablets are very suitable for infants, the elderly, and people who have difficulty swallowing, to improve patients' compliance with medication; for throat diseases, Parkinson's disease, AIDS, thyroid surgery, head and neck radioth...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K9/20A61P31/04
Inventor 闫志刚曾环想王磊
Owner SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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