Production process of microporous carbon hydroxyapatite

A technology of porous carbon hydroxyapatite and production method, which is applied in the field of preparation of micron porous carbon hydroxyapatite, which can solve the problems of excessive pore size, expensive raw materials, high sintering temperature, etc., and achieve the effect of strong curing ability and cost reduction

Inactive Publication Date: 2006-08-02
WUHAN CHEM COLLEGE
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Problems solved by technology

[0004] In order to solve the problems of high sintering temperature above 600°C, expensive raw materials, and too large pore size in the production process of microporous hydroxyapatite, the technical solution is: select natural phosphorite, add acid to adjust pH = 4-6 Dissolve the phosphorite, subject to the complete dissolution of phosphorus and calcium, filter to remove insoluble impurities, the impurities are mainly quartz and clay, add appropriate amount of urea and ethylenediaminete

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  • Production process of microporous carbon hydroxyapatite

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[0007] Example 1

[0008] First select natural phosphate rock, add hydrochloric acid to adjust the pH to 5.5, and filter to remove insoluble impurities. The impurities are mainly quartz and clay. Add appropriate amount of urea and ethylenediamine to the filtrate. Acetic acid (EDTA) solution, make the solution by weight percentage: calcium: phosphorus: urea: EDTA ratio = 12.0:5.4:15.0:0.5, adjust the pH of the solution to 4.5 with hydrochloric acid, whichever is not precipitated, put it in A homogeneous system is made in the autoclave. When heated to 95℃~100℃, urea is slowly hydrolyzed to release hydroxyl and carbonate, and a lot of bubbles are released at the same time. After reaching supersaturation, the bubble boundary induction / homogeneous precipitation reaction begins. After 5h Stop heating, leave it to stand for 12 hours, wash, filter, granulate, and dry, and finally obtain the carbon hydroxyapatite with a pore size of 0.8 μm and doped with carbonate, and its shape is microsp...

Example Embodiment

[0009] Example 2

[0010] First select 1Kg of natural phosphate rock, add hydrochloric acid to adjust the pH to 5.5, and filter to remove insoluble impurities, mainly quartz and clay, based on the dissolution of phosphorus and calcium. Add 0.5Kg of urea and 0.0167kg of EDTA to the filtrate The solution, adjust the pH of the solution to 4.5 with hydrochloric acid, and place it in an autoclave to form a homogeneous system, which is subject to no precipitation. When heated to 140℃~145℃, urea is slowly hydrolyzed to release hydroxyl and carbonate, and a lot of bubbles are released at the same time After reaching the supersaturation, the bubble boundary induction / homogeneous precipitation reaction begins. After 5 hours, the heating is stopped, and it is allowed to stand for 12 hours, washed, filtered, granulated, and dried. Finally, the carbon with a pore size of 0.5μm doped with carbonate is obtained. Hydroxyapatite has a microsphere shape.

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Abstract

The present invention process of microporous carbon hydroxyapatite with natural rock phosphate as material includes dissolving and eliminating impurity; compounding homogeneous Ca, P, urea and EDTA system; and foam inducing and homogeneous precipitation to obtain microporous carbon hydroxyapatite with pore size of 0.5-10 micron. The product has excellent organic and biological compatibity, ion exchange property, etc. as well as powerful protein separating, solid alkali catalysis, medicine carrying, radioactive substance solidifying and other capacity. It may be used in porous biological material, protein separation, chromatography, catalyst, catalyst carrier, medicine carrier, radioactive substance treatment and other fields.

Description

technical field [0001] The invention relates to a production method for preparing microporous carbon hydroxyapatite. Background technique [0002] At present, the known methods for preparing microporous hydroxyapatite include the following: 1. Animal hard tissue burning method; 2. Hard template pore-forming powder sintering method. Its characteristics are: ① High temperature sintering is required, above 600 ° C; ② The production raw materials used are chemical products and cannot use cheap natural phosphorite, so its production cost is high; ③ The pore size is too large, reaching more than 10 μm, which greatly affects limited its scope of application. Contents of the invention [0003] The purpose of the present invention is to overcome the defects and problems of the above-mentioned prior art, to provide a production method for microporous hydroxyapatite, which can make the microporous hydroxyapatite product be produced und...

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Application Information

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IPC IPC(8): C04B35/447C04B38/00
Inventor 黄志良何前军陈伟刘羽
Owner WUHAN CHEM COLLEGE
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