Medicinal composition with glycosamine hydrochloride and cartilagin sulfate as active components, its preparation and use thereof

Abstract

A medicinal composition in the form of tablet, capsule, dispersing tablet, effervescent tablet, etc for treating the various osteoarthritides is prepared from aminoglucose hydrochloride, chondroitin sulfate and pharmacologically acceptable additives.

Description

technical field [0001] The invention relates to a pharmaceutical composition with glucosamine hydrochloride and chondroitin sulfate as active components, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Osteoarthritis is a degenerative chronic joint disease. The clinical manifestations are pain, swelling, and limited movement of the affected joints. In advanced patients, symptoms and signs such as cartilage spalling, bone spur formation, and subchondral osteonecrosis may appear, resulting in loss of joint function. , Severe cases must undergo artificial joint conversion surgery. [0003] Osteoarthritis is a major disease that causes functional disability, economic loss, and social development in people over the age of 50. my country's epidemiological survey shows that the population prevalence of osteoarthritis is 9.6%, and the estimated incidence is related to age. Among the population over 65 years...

AI Technical Summary

Problems solved by technology

[0004] Early first-line drugs for the treatment of osteoarthritis include: paracetamol, topical analgesics, and non-steroidal anti-inflammatory drugs. The use of these drugs is accompanied by serious side effects—corresponding effects of gastric ulcer, IIR functional impairment, and prolonged bleeding time. appear, and NSAIDs only relieve the symptoms of patients with osteoarthritis, but cannot change the development of their lesions