Hydrothermal process of preparing nanometer hydroxyapatite colloid

A technology of nano-hydroxyapatite and hydrothermal method, which is applied in the field of preparation of nano-hydroxyapatite colloid by hydrothermal method, which can solve the problems affecting the application, easy agglomeration of nanoparticles, particle agglomeration, etc.

Active Publication Date: 2006-10-18
成都迪康中科生物医学材料有限公司
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Problems solved by technology

This method uses drying, calcination and other processes, and the nanoparticles are easy to agglomerate
Chinese patent ZL200310105951.7 adopts sonochemical synthesis of nano-hydroxyapatite by adding urea into the reaction system of calcium nitrate and diammonium hydrogen phosphate. In the post-treatment process, processes such as filtration and vacuum drying are used, and these treatments are also likely to lead to particle agglomeration.
], this method will leave emulsifiers on the surface of nanoparticles, which will affect its application

Method used

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Examples

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Comparison scheme
Effect test

Embodiment

[0025] Examples 1-18 are the synthesis of nano-hydroxyapatite colloids. The formulation components used therein are shown in Table 1 in detail. For the convenience of description, the reaction is divided into two stages. The stage of adding liquid B to liquid A is called "nucleation reaction stage". This stage is mainly to generate hydroxyapatite crystals. After the B liquid is added dropwise, it is mainly the hydroxyapatite particle dispersion stage, which is called the "HA particle dispersion stage". The process control parameters of these two stages are shown in Table 2. The specific synthesis process is as follows: take citrate and calcium salt according to the formula, dissolve them in the water of the formula amount, and adjust the required pH value with alkali to form A liquid. Weigh the phosphate according to the formula, make it into the concentration set in Table 1, and adjust the pH value with alkali to form B liquid. Add liquid A into the three-necked bottle, ra...

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Abstract

The present invention discloses hydrothermal process of preparing nanometer hydroxyapatite colloid. The preparation process includes the following steps: 1. dissolving citrate of 0.774-309.6 weight portions and calcium salt of 1.64-262.6 weight portions in water of 200-5000 weight portions to compound solution A; 2. dissolving phosphate of 0.894-357.6 weight portions and forming Ca/P weight ration of 1.5-1.67 in water of 50-1200 weight portions to compound solution B; 3. heating solution A to 20-60 deg.c, preferably to 40-50 deg.c, and dropping solution B to solution A in 5-60 min; 4. heating after dropping to 60-100 deg.c while stirring to react for 2-6 hr to obtain nanometer hydroxyapatite colloid particles dispersed stably in water phase; and 5. ultrafiltering to eliminate salt from the nanometer hydroxyapatite colloid solution until reaching the filtrate conductivity of 20-200 microsecond/cm to obtain the purified nanometer hydroxyapatite colloid solution.

Description

technical field [0001] The invention relates to a method for preparing nano-hydroxyapatite colloid by a hydrothermal method, which belongs to the field of synthesis of nano-biological ceramics. Background technique [0002] The main components of inorganic substances in human hard tissues (teeth and bones) are hydroxyapatite HA, calcium-deficient hydroxyapatite, fluorine-substituted hydroxyapatite, and carbonate-substituted hydroxyapatite. Therefore, from the perspective of bionics, it is best to use HA materials as human hard tissue replacement materials. Human bones are formed by the orderly deposition of nano-phase HA in the collagen matrix. Therefore, many studies at home and abroad tend to use nano-HA, collagen, polylactic acid (PLA), etc. as nanocomposite materials, and further use them as machinery and devices for bone repair and internal fixation of fractures, such as HA / PLA screws for internal fixation of fractures. However, due to the inherent agglomeration chara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/624
Inventor 谢兴益熊成东钟银屏
Owner 成都迪康中科生物医学材料有限公司
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