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Ovotransferrin iron supplement agent, and its preparing method and use

A technology for transferring protein and iron ions, which is applied in the field of egg iron ion transfer protein and egg iron ion transfer protein iron supplements, can solve problems such as damage and separation, and achieve the effects of reducing side effects, promoting metabolism, and stabilizing the structure

Inactive Publication Date: 2006-10-25
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the iron-EDTA chelate can be smoothly absorbed from the intestine into the blood, the high stability creates problems associated with the iron-EDTA chelate, which is too high for the body to readily remove iron from the ligand. isolated on
Also, even if metal ions and EDTA ligands can be separated, the substance can cause damage to the body because EDTA is a strong chelating agent

Method used

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  • Ovotransferrin iron supplement agent, and its preparing method and use
  • Ovotransferrin iron supplement agent, and its preparing method and use
  • Ovotransferrin iron supplement agent, and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of egg ferric ionotransfer protein iron supplement powder

[0027] Raw materials: ferric chloride, egg white

[0028] The preparation method comprises the following steps:

[0029] (1) After homogenizing the egg white at 30MPa, dilute it with 4 times normal saline, stir evenly, and filter with a filter cloth to remove insoluble matter therein;

[0030] (2) configuration mass ratio 1% ferric chloride solution, at room temperature, 0.44ml ferric chloride solution is added dropwise in the egg white after the above-mentioned dilution of 10ml, stir evenly, egg ferritin can make iron ion saturation ( See image 3 );

[0031] (3) After the reaction solution is clarified, dialyze with cellophane to obtain the first product, wherein the content of iron is 0.465mg / ml;

[0032] (4) The first product is dried in a freeze dryer to obtain the original powder of iron supplement.

Embodiment 2

[0033] Example 2 Animal Test of Egg-Iontransferrin Iron Supplement (Effects on Red Blood Cell Count (RBC) and Liver SOD and Serum MDA Activity in Anemia Model Mice)

[0034] Experimental materials: Kunming mice, 8 weeks old, body weight (20.0±2.0) g, half male and half male;

[0035] The Fe content of this iron supplement is 3.1mg / ml; red blood cell diluent;

[0036] Superoxide dismutase (SOD) test kit and malondialdehyde (MDA) test kit.

[0037] Experimental method: 50 mice were randomly divided into four groups: positive control group (I), positive control group (II), experimental group and negative control group, with half male and half female in each group. Subcutaneous injection of 2% phenylhydrazine at a weight of 0.04ml / kg resulted in normal mouse activity without death, thereby establishing an anemia model in mice. See Table 1 for grouping, gavage method and dosage. The content of red blood cells in mice was measured 2 days after injection. Afte...

Embodiment 3

[0045] Embodiment 3 Preparation of iron supplement oral tablet

[0046] Raw material formula:

[0047] Iron supplement raw powder 1 part by weight

[0048] Vitamin B12 0.02~0.05 parts by weight

[0049] Magnesium stearate 0.08~0.2 parts by weight

[0050] Microcrystalline cellulose 0.5~0.6 parts by weight

[0051] Compressible starch 0.5-0.6 parts by weight

[0052] Preparation method: After fully mixing iron supplement powder, vitamin B12, magnesium stearate, microcrystalline cellulose and compressible starch, adding appropriate amount of water and mixing, granulating, drying, and tableting.

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Abstract

The present invention relates to an egg iron-ion transferring iron-supplementing preparation. Said iron-supplementing preparation contains the coordination compound formed from egg iron-ion transferring and ferric ion, the mole ratio of egg iron-ion transferring and ferric ion is 1:0.5-2. Said coordination compound has maximum absorption peak at 465 nm. Besides, said invention also provides the preparation method of said iron-supplementing preparation and its concrete steps.

Description

technical field [0001] The invention relates to an iron ion transfer protein, in particular to an egg iron ion transfer protein, and specifically belongs to an egg iron ion transfer protein iron supplement and a preparation method and application thereof. Background technique [0002] Iron deficiency anemia (IDA) is the most common anemia, seriously affecting human health. Iron deficiency ranks ninth among the risk factors that seriously affect human health released by the World Health Organization in 2002. IDA is still a common and serious health problem in all countries in the world. Improving the nutritional status of iron is a public health problem that the world and our country urgently need to solve. [0003] The development of iron nutritional fortifiers has gone through three stages: Inorganic iron salts represented by ferrous sulfate, that is, the first generation of fortifier products. Its side effects such as nausea, vomiting, diarrhea, metallic odor, etc., and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/40A61P7/06
Inventor 黄登宇赵艮贵宗艳杨斌盛张立伟宋强任瑞霞刘超卢臣
Owner SHANXI UNIV
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