Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Aquogel type thiamazole plaster preparation

A methimazole and hydrogel technology, applied in the field of medicine, can solve the problems of poor air permeability and water permeability, loss of viscosity, environmental pollution, etc., and achieve the effects of excellent bonding performance, improved cohesive strength, and no environmental pollution.

Inactive Publication Date: 2006-11-08
HUAZHONG UNIV OF SCI & TECH +1
View PDF1 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a kind of hydrogel-type methimazole patch with good biocompatibility with skin, good breathable and water-permeable performance, repeated peeling, suitable bonding performance, large drug loading capacity and good percutaneous penetration effect , to overcome the poor biocompatibility of the patches prepared by traditional pressure-sensitive adhesives, poor air permeability and water permeability, which lead to skin damage caused by long-term use, poor percutaneous penetration of drugs, and loss of viscosity when exposed to water, cannot be repeatedly peeled off, excessive peel strength, and in production Organic solvents cause environmental pollution and other disadvantages

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Aquogel type thiamazole plaster preparation
  • Aquogel type thiamazole plaster preparation
  • Aquogel type thiamazole plaster preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0051] The present invention is further illustrated by the following examples, and the prescription composition and properties of Examples 1-18 are listed in Table 1 and Table 2, respectively.

[0052] The content disclosed in the present invention can be implemented by those skilled in the art with reference to the above-mentioned embodiments. Therefore, the preferred specific embodiments of the present invention should be understood as merely illustrative and not limiting the present invention in any way.

[0053] Real

Give

example

Methionine

Imidazole

Content

(G)

PAA molecular weight

(10,000) / segment ratio / including

Quantity (g)

Crosslinking agent / content

(G)

pH adjustment

Agent / content

(G)

Humectant / content

(G)

Tackifier / content

(G)

Penetration enhancer / containing

Quantity (g)

Other / content

(G)

1

0.75

0.5 / 1∶1 / 3.0

Alu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The aquogel type thiamazole plaster includes a back lining layer, a medicine matrix layer and a protecting film. The medicine matrix layer contains medicine thiamazole in 0.2-20 wt% of the medicine matrix layer, aquogel type contact adhesive material, cross-linking agent, pH regulator, humectant, tackifier medicine, transdermal promoter and water, . The present invention has high transdermal effect of medicine, good skin compatibility, high air and moisture permeability, lowered toxicity and side effect of medicine and other advantages, and is used for treating hyperthyroidism.

Description

Technical field [0001] The invention relates to a hydrogel type methimazole patch, which belongs to the technical field of medicine. Background technique [0002] Hyperthyroidism (hyperthyroidism for short) is a common endocrine disease caused by increased thyroid function and excessive secretion of thyroid hormones, leading to an increase in the basal metabolic rate. Thiamazole (also known as tapazole, methylthioimidazole, thiothiazole, mecarzolil) can inhibit the synthesis of thyroid hormones and is a representative drug for the clinical treatment of hyperthyroidism. Its chemical name is 1 -Methylimidazole-2-thiol, molecular formula: C 4 H 6 N 2 S (molecular weight: 114.16). [0003] At present, the commonly used preparation for clinical treatment of hyperthyroidism is methimazole tablets. Due to the short biological half-life of methimazole (less than 3 hours), the oral dose of the drug is large, the frequency of administration is frequent, and the treatment of patients is inc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4164A61K9/70A61K47/00A61P5/16
Inventor 刘卫周小顺左新河陈如泉魏小藏杨祥良
Owner HUAZHONG UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com