Aquogel type thiamazole plaster preparation
A methimazole and hydrogel technology, applied in the field of medicine, can solve the problems of poor air permeability and water permeability, loss of viscosity, environmental pollution, etc., and achieve the effects of excellent bonding performance, improved cohesive strength, and no environmental pollution.
Inactive Publication Date: 2006-11-08
HUAZHONG UNIV OF SCI & TECH +1
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Problems solved by technology
[0008] The object of the present invention is to provide a kind of hydrogel-type methimazole patch with good biocompatibility with skin, good breathable and water-permeable performance, repeated peeling, suitable bonding performance, large drug loading capacity and good percutaneous penetration effect , to overcome the poor biocompatibility of the patches prepared by traditional pressure-sensitive adhesives, poor air permeability and water permeability, which lead to skin damage caused by long-term use, poor percutaneous penetration of drugs, and loss of viscosity when exposed to water, cannot be repeatedly peeled off, excessive peel strength, and in production Organic solvents cause environmental pollution and other disadvantages
Method used
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[0051] The present invention is further illustrated by the following examples, and the prescription composition and properties of Examples 1-18 are listed in Table 1 and Table 2, respectively.
[0052] The content disclosed in the present invention can be implemented by those skilled in the art with reference to the above-mentioned embodiments. Therefore, the preferred specific embodiments of the present invention should be understood as merely illustrative and not limiting the present invention in any way.
[0053] Real
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Content
(G)
PAA molecular weight
(10,000) / segment ratio / including
Quantity (g)
Crosslinking agent / content
(G)
pH adjustment
Agent / content
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Humectant / content
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Tackifier / content
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Penetration enhancer / containing
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1
0.75
0.5 / 1∶1 / 3.0
Alu...
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The aquogel type thiamazole plaster includes a back lining layer, a medicine matrix layer and a protecting film. The medicine matrix layer contains medicine thiamazole in 0.2-20 wt% of the medicine matrix layer, aquogel type contact adhesive material, cross-linking agent, pH regulator, humectant, tackifier medicine, transdermal promoter and water, . The present invention has high transdermal effect of medicine, good skin compatibility, high air and moisture permeability, lowered toxicity and side effect of medicine and other advantages, and is used for treating hyperthyroidism.
Description
Technical field [0001] The invention relates to a hydrogel type methimazole patch, which belongs to the technical field of medicine. Background technique [0002] Hyperthyroidism (hyperthyroidism for short) is a common endocrine disease caused by increased thyroid function and excessive secretion of thyroid hormones, leading to an increase in the basal metabolic rate. Thiamazole (also known as tapazole, methylthioimidazole, thiothiazole, mecarzolil) can inhibit the synthesis of thyroid hormones and is a representative drug for the clinical treatment of hyperthyroidism. Its chemical name is 1 -Methylimidazole-2-thiol, molecular formula: C 4 H 6 N 2 S (molecular weight: 114.16). [0003] At present, the commonly used preparation for clinical treatment of hyperthyroidism is methimazole tablets. Due to the short biological half-life of methimazole (less than 3 hours), the oral dose of the drug is large, the frequency of administration is frequent, and the treatment of patients is inc...
Claims
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Login to View More IPC IPC(8): A61K31/4164A61K9/70A61K47/00A61P5/16
Inventor 刘卫周小顺左新河陈如泉魏小藏杨祥良
Owner HUAZHONG UNIV OF SCI & TECH