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Traditional Chinese medicine soft capsule for eliminating thrombus and removing obstruction in channels, its prepn. method

A technology for eliminating blood clots, dredging collaterals, and soft capsules, which can be used in capsule delivery, pharmaceutical formulations, and drug combinations. It can solve the problems of single pharmaceutical formulations and achieve stable product quality, no harmful residues, and simple preparation processes.

Inactive Publication Date: 2006-11-29
浙江天一堂医药管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the finished drug form is relatively simple, and there are only two kinds of granules and capsules.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 5.7 parts of borneol and grind into fine powder, 144 parts of Panax notoginseng into fine powder, and the remaining 287 parts of Chuanxiong, 215 parts of Salvia, 431 parts of Astragalus, 144 parts of Alisma, 72 parts of Sophora japonica, 144 parts of Guizhi, 144 parts of Curcuma, 72 parts of incense, 144 parts of hawthorn and nine flavors are boiled three times with water, the first time is 1 hour, the second time is 1 hour, the third time is 2 hours, the decoction is combined, filtered, the filtrate is left standing, and the supernatant is taken Concentrate the solution to a clear paste with a relative density of 1.17 to 1.19 (80°C), dry, pulverize, add notoginseng fine powder, borneol fine powder, and mix to obtain the main drug fine powder.

[0025] Take by weighing 100g of the above-mentioned principal agent fine powder, add 897g of soybean oil containing 4% beeswax, 1.9g of dibutyl hydroxytoluene, 0.2g of benzyl p-hydroxyformate, and 1.9 of opacifier, and grind...

Embodiment 2

[0027] The preparation method of the main drug fine powder is the same as that of the previous example.

[0028] Take by weighing 600g of the above-mentioned principal agent fine powder, add 397g of soybean oil containing 4% beeswax, 1.9g of dibutyl hydroxytoluene, 0.2g of benzyl p-hydroxyformate, and 1.9 of sunscreen, and grind for 2 minutes through a colloid mill to prepare Obtain the contents of the soft capsule. Weigh glycerin, water, and gelatin in proportion (1-3:3-6:2.9-5.5), mix glycerin and water evenly, put them into a plastic tank, add gelatin when heated to 65°C, stir and heat to 65°C , keep warm for 40 minutes, evacuate (-0.02~-0.06MPa), stir for about 1 hour, until there are no bubbles in the tank, pass through a 60-mesh filter and place it in a heat preservation tank, keep warm at about 60°C, and prepare a rubber solution for later use . Start the soft capsule machine, and after the rubber runs to meet the requirements, use liquid paraffin to adjust the weight...

Embodiment 3

[0030] The preparation method of the main drug fine powder is the same as that of the previous example.

[0031]Take by weighing 200g of the above-mentioned principal agent fine powder, add 797g of soybean oil containing 4% beeswax, 1.9g of dibutyl hydroxytoluene, 0.2g of benzyl p-hydroxyformate, 1.9 of opacifier, and grind for 2 minutes through a colloid mill to prepare Obtain the contents of the soft capsule. Weigh glycerin, water, and gelatin according to the ratio (1.5-2.5:3.5-5:3.5-4.5), mix glycerin and water evenly, put them into a plastic tank, add gelatin when heated to 65°C, stir and heat to 60°C , keep warm for 40 minutes, evacuate (-0.02~-0.06MPa), stir for about 1 hour, until there are no bubbles in the tank, pass through a 60-mesh filter and place it in the heat preservation tank, keep warm at about 55°C, and prepare the rubber solution for later use . Start the soft capsule machine, and after the rubber runs to meet the requirements, use liquid paraffin to adj...

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PUM

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Abstract

A Chinese medicine in the form of soft capsule for eliminating thrombus and unblocking collaterals is composed of a core prepared from 11 Chinese-medicinal materials including borneol, notoginseng, Chuan-xiong rhizome, red sage root, etc and a shell prepared from gelatin or polyethanediol, glycerine, additive and water. Its preparing process is also disclosed.

Description

technical field [0001] The present invention relates to a kind of Chinese patent medicine and its preparation method, especially a kind of Chinese herbal medicine Chuanxiong, Danshen, Astragalus, Alisma, Panax notoginseng, Sophora japonica, Guizhi, turmeric, woody fragrance, borneol and hawthorn. Traditional Chinese medicine Xiaoshuantongluo soft capsule as raw material of medicine and preparation method thereof. Background technique [0002] Xiaoshuan Tongluo traditional Chinese medicine preparation is composed of eleven medicinal materials such as Chuanxiong, Danshen, Astragalus, Alisma, Panax notoginseng, Sophora japonica, Guizhi, turmeric, woody, borneol, and hawthorn. It is an anticoagulant and thrombolytic drug. Rich in KPT factor, through the hemodynamic effect, it can achieve the triple resistance effect of anti-blood viscosity, anti-coagulation and anti-thrombosis, rapidly improve microcirculation, resist local ischemia and hypoxia, promote...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/48A61P7/02A61P9/10
Inventor 王天亮樊雪君王永华
Owner 浙江天一堂医药管理有限公司
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