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Soft capsule for eliminating breast lump,and preparation method

A milk block and softening technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as relatively high requirements for storage conditions, inconvenient carrying of oral liquids, and slow disintegration and dissolution processes , to achieve the effect of clean and beautiful appearance, high drug bioavailability, and fast disintegration and dissolution

Inactive Publication Date: 2006-12-06
张颀 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Tangerine leaf, Salvia miltiorrhiza, Saponaria thorn, Wang Buliuxing, Toosendan, and earthworm are commonly used medicinal materials, mainly used for the prevention and treatment of mammary gland hyperplasia, and have a wide range of uses. Hard capsule preparations, the production cost of these preparations is low, but there is certain problem: its taste is not good, mouthfeel is poor, as: make oral liquid, granule, add flavoring agent more to adjust mouthfeel, can not cover its mouthfeel completely. Unpleasant taste and inconvenient swallowing; oral liquids and hard capsules generally have relatively high requirements for storage conditions, because oral liquids are liquid preparations, which are prone to deterioration, and oral liquids are inconvenient to carry; granules and hard capsules are easy to absorb moisture The general stability of the preparation is poor. Although the oral liquid and granule do not have a disintegration and dissolution process in the body, due to the aforementioned deficiencies; the disintegration and dissolution process of the hard capsule in the body is slow, and the effect is slow; The substance content is low, the dosage is large and the therapeutic effect is not obvious
There is no report of making it into soft capsule preparations in existing products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Tangerine leaves and Salvia miltiorrhiza each 825g; saponin thorns and toosendan 550g each, add 4 times water to decoct once, filter, concentrate the filtrate to a relative density of 1.25-1.30 at 85°C (85°C), let cool, and set aside; Earthworm and Wangbuliuxing were extracted twice with 70% ethanol under reflux, firstly add 10 times the amount of ethanol, extract for 2 hours, add 8 times the amount of ethanol for the second time, extract for 1 hour, filter, combine the filtrates, add the above In the concentrated solution, adjust the amount of ethanol to 70%, stir evenly, let stand, recover the ethanol and concentrate to a thick paste, and dry under reduced pressure to obtain the milk cube extract. Mesh sieve to get the milk extract extract powder, calculated by weight components: get the milk extract extract powder, vegetable oil, and beeswax to make a suspension according to 4:0.9:0.01, then use gelatin, glycerin, and water as raw materials 1. Prepare the rubber acco...

Embodiment 2

[0009] Tangerine leaf and Salvia miltiorrhiza each 825g; saponin thorn and toosendan 550g each, decocted three times with 12 times of water, filtered, and the filtrate was concentrated to a relative density of 1.25-1.30 at 85°C, let it cool, and set aside; Reflux extraction with 70% ethanol for two times, add 10 times the amount of ethanol for the first time, extract for 2 hours, add 8 times the amount of ethanol for the second time, extract for 1 hour, filter, combine the filtrates, add to the above concentrated solution, Adjust the amount of ethanol to 70%, stir evenly, let stand, recover ethanol and concentrate to a thick paste, dry under reduced pressure to obtain Rukuaixiao extract, take Rukuaixiao extract, crush it, and pass through a 100-mesh sieve to obtain Rukuaixiao extract powder, calculated by weight components: take Rukuaixiao extract powder, vegetable oil, and beeswax to make a suspension at a ratio of 4:9:0.12, then use gelatin, glycerin, and water as raw materia...

Embodiment 3

[0011] Tangerine leaves and Salvia miltiorrhiza each 825g; saponin thorn and toosendan 550g each, decocted twice with 8 times water, filtered, and the filtrate was concentrated to a relative density of 1.25-1.30 at 85°C, let it cool, and set aside; earthworm, Wangbuliuxing was extracted twice with 70% ethanol under reflux. For the first time, add 10 times the amount of ethanol, extract for 2 hours, add 8 times the amount of ethanol for the second time, extract for 1 hour, filter, combine the filtrates, and add to the above concentrated solution , adjust the amount of ethanol to 70%, stir evenly, let stand, reclaim ethanol and concentrate to a thick paste, dry under reduced pressure to obtain the milky extract, take the milky extract and pulverize, pass through a 100-mesh sieve, Obtain the milk extract extract powder, calculate by weight component: get the milk extract extract powder, vegetable oil, beeswax and make suspension by 4: 3.9: 0.1, then take gelatin, glycerin, water a...

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PUM

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Abstract

A Rukuaixiao softgel for treating breast nodules is composed of shell and core which is a suspension of Rukuaixiao powder, plant oil and beeswax. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a manufacturing method of medicines, in particular to a Rukuai Xiaoruan capsule and a preparation method thereof. technical background [0002] Tangerine leaf, Salvia miltiorrhiza, Saponaria thorn, Wang Buliuxing, Toosendan, and Earthworm are commonly used medicinal materials, mainly used for the prevention and treatment of mammary gland hyperplasia, and have a wide range of uses. The existing milk lump elimination preparations are generally tablets, Hard capsule preparations, the production cost of these preparations is low, but there is certain problem: its taste is not good, mouthfeel is poor, as: the milk cube is made into oral liquid, granule, more flavoring agent is adjusted mouthfeel, can not cover up its Unpleasant taste and inconvenient swallowing; oral liquids and hard capsules generally have relatively high requirements for storage conditions, because oral liquids are liquid preparations, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/48A61P15/14
Inventor 张颀潘斌俞达郭卫东
Owner 张颀
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