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Process for producing coated preparation having relieved unpleasantness

A manufacturing method and preparation technology, which are applied in the manufacturing field of coated preparations, can solve problems such as incomplete masking, and achieve the effect of improving unpleasant taste

Active Publication Date: 2006-12-06
SHIONOGI & CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is pointed out that the masking of the coated preparation is not complete, so the original drug is exposed on the surface of the granule, and a bitter taste can be felt

Method used

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  • Process for producing coated preparation having relieved unpleasantness
  • Process for producing coated preparation having relieved unpleasantness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] (1) Plain tablet (granulation process)

[0079] The plain tablet ingredients of the 2 components shown in the table below were mixed for 15 minutes with a V-blender (50 L). After molding the mixed powder into flakes with a roller compressor (ロ-ラ-コンパクタ-・タ-ボ Industries Co., Ltd.), use a roller granulator (Japan Granulator (Co., Ltd.)) to adjust the granulation, and use a vibrating sieving machine to Sieve to obtain 30-100 mesh plain tablets.

[0080] (2) Hot melt coating process

[0081] The plain tablet is packed into the fluidized bed drying device (Frokota-FLO-5 type; Ogawara Manufacturing Co., Ltd.), heated to a product temperature of 80-85° C., and the hardened castor oil is dropped into the in the fluid layer. After being made to flow for 10 to 30 minutes at a product temperature of 80 to 85° C., it was passed through a 30-mesh screen to obtain hot-melt coated granules.

Embodiment 2

[0083] Carry out in the same manner as in Example 1. The compositions of Examples 1 and 2 are shown in Table 2.

[0084] Example 1

reference example 1

[0087] (1) Plain tablet (granulation process)

[0088] The components listed in Table 3 were mixed for 15 minutes with a V-type mixer (50 L). After molding the mixed powder into flakes with a roller compressor, adjust the granulation with a roller granulator stand, and sieve with a vibrating sieving machine to obtain plain tablets of 30 to 100 meshes.

[0089] (2) Thermal melting (heating) process

[0090] Put the plain tablet into a fluidized bed drying device, and let it flow for 30 to 40 minutes at a product temperature of 80 to 85° C., then pass through a 30-mesh screen to obtain hot-melt granules.

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Abstract

A coated preparation having a relieved unpleasantness can be produced by heating uncoated grains which contains a drug compound and a waxy substance, adding a powdery waxy substance at such a temperature as moistening the surface of the former waxy substance, and then hot-melt coating the surface of the uncoated grains. The dosing properties of the coated preparation can be further improved by blending sweetening subtilaes, which have been obtained by the wet granulation method with the use of a binder liquor having a sweetener and a binder dissolved or dispersed therein, therewith.

Description

technical field [0001] The present invention relates to a method for producing coated preparations, in particular, to a method for manufacturing coated preparations containing unpleasant-tasting pharmaceutical compounds. Background technique [0002] When the drug has an unpleasant taste such as bitterness, it is particularly difficult for patients to take it by oral preparation (particularly powder or granule). Therefore, in order to mask the unpleasant taste in the mouth when ingested, processing such as coating is generally performed. A film coating method is known in which a film of sugar or the like is formed on the surface to mask the bitter taste, but the sugar coating process is very complicated. In addition, in these cases, the drug is usually molded into granules, tablets, etc. and then coated. The smaller the particle size, the easier it is to powder, and it is difficult to prevent the oozing of unpleasant taste. Although there is also a method of adding a flavo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/10A61K47/12A61K47/44A61K31/546A61K9/50
CPCA61K9/5089A61K31/546A61K9/1682A61P31/04A61K9/16A61K9/28
Inventor 田中宏本多刚北岛秀明
Owner SHIONOGI & CO LTD
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