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A medicine for treating hepatitis and preparation process thereof

A drug and hepatitis technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of old drug impact, affecting drug dissolution and bioavailability, curative effect rebound, etc., to achieve low cost , improve bioavailability, and ensure the effect of curative effect

Inactive Publication Date: 2006-12-13
孙民富
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to research, the market sales of this drug are currently shrinking. One is that new drugs for the treatment of hepatitis continue to come out, and the old drugs are impacted. The main reason is that silymarin itself is an insoluble flavonoid compound, but it is made into tablets. , the dosage form itself has problems affecting the dissolution rate and bioavailability of the drug; although the bifendate dripping pills have solved the problems in the dissolution rate and bioavailability of the drug, the long-term curative effect is reversed. The weakness of jumping is very prominent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0029] Embodiment (taking the dropping pill as an example)

[0030] Take 16g of silibinin and 3g of bifendate, grind them into fine powder, put them in a container and mix them evenly with 81g of polyethylene glycol 4000, heat them on a boiling water bath until the matrix dissolves, stir at high speed, and keep warm for 20 minutes to make it Become a molten liquid; transfer the above molten liquid to the liquid storage tank of the dripping pill machine, make it in a suitable vacuum state, keep it at 80°C for 30 minutes, and stir at a speed of 15 rpm; add cooling liquid to the cooling column Dimethicone, drop the molten liquid into the cooling liquid to prepare 1000 dropping pills, each 100 mg; collect the dropping pills, remove the cooling liquid on the surface, sieve and dry.

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PUM

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Abstract

The invention relates to a medicament for treating acute hepatitis, chronic hepatitis and persistent hepatitis, and process for preparation, wherein the medicament is prepared from silibinin-N-methylglucamine and biphenyldicarboxylate as the main constituent, and right mxtrix through a predetermined processing combinations. Compared with the existing dosage forms, the drop pill preparation has the advantages of short technological process, low cost of production and quick-effectiveness.

Description

(1) Technical field [0001] The invention belongs to the technical field of medicines for treating acute and chronic hepatitis, in particular to a medicine formula for treating acute and chronic hepatitis and a preparation process thereof. (2) Background technology [0002] Bifendate and silibinin or silibinin meglumine salt combined with silybin and meglumine has been the main drug for the treatment of acute and chronic hepatitis, and has a significant curative effect. [0003] Bifendate (Biphenyldicarboxylate); this product is an enzyme-lowering drug for the treatment of hepatitis created in my country, and is an intermediate for the synthesis of Schisandra C. Pharmacological experiments have proved that oral administration of this product in mice can reduce the increase of serum alanine aminotransferase caused by carbon tetrachloride and thioacetamide. This product can also enhance liver detoxification function, reduce liver pathological damage, promote liver cell regener...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/36A61P1/16A61P31/14A61K31/357
Inventor 孙民富
Owner 孙民富
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