Anion-binding polymers and uses thereof

A technology combining polymers and ions, applied in detergent compositions, surface active detergent compositions, chemical instruments and methods, etc., can solve problems such as side effects, discomfort, swelling, etc.

Inactive Publication Date: 2006-12-13
ILYPSA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

First, the polymer will swell in the mouth and cause a very unpleasant sensation (dry mouth, choking)
Second, even if the patient can overcome the discomfort in the mouth, taking the

Method used

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  • Anion-binding polymers and uses thereof
  • Anion-binding polymers and uses thereof
  • Anion-binding polymers and uses thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0088] B. Polymer Preparation

[0089] The polymers of the present invention are prepared by methods well known to those skilled in the art. For example, ionically bound monomers or their precursors can be copolymerized in the presence of crosslinking agents; pre-synthesized ionically bound polymers are crosslinked by chemical reactions or radiation exposure; or polymer precursors are first Cross-linking, and further reacting on the polymer to generate ion-binding functional groups.

[0090] Polymers can be obtained by techniques such as direct or reverse suspension, emulsification, precipitation, polymerization in aerosol or by bulk polymerization / crosslinking methods, and size reduction processes such as extrusion and milling. Processes can be batch, semi-continuous and continuous.

[0091] Swell rate, binding interference, binding capacity and molecular weight (MW) exclusion limit etc. will be affected by at least the following compositional and process variables:

[009...

Embodiment 1

[0313] Embodiment 1: the assay method of phosphate binding capacity

[0314] This example describes various methods that can be used to determine the amount of anion incorporation in a polymer, where the anion is phosphate.

[0315] Determination of phosphate binding in non-interfering buffer

[0316] A sample amount of dry polymer P (gr) was mixed with a fixed volume V (L) of buffer containing 20 mM H 3 PO 4 , 80 mM NaCl, 100 mM MES sodium salt (morpholineethanesulfonic acid) and pH 6.5. This buffer can be used when performing a single binding assay. When performing multiple binding assays and drawing a binding isotherm, the concentration of buffer phosphate can be varied. The initial concentration of phosphate in the buffer is defined as P start (mM). This buffer is called a non-interfering buffer because it does not contain solutes that would compete with phosphate for binding to the polymer. After reaching equilibrium with the polymer, the solution was separated by ...

Embodiment 2

[0327] Example 2: Generation of cross-linked polymer libraries using bulk solution method and determination of phosphate incorporation to generate polymer libraries

[0328] The following five examples each include one polymer library, and each polymer library contains up to 24 cross-linked polymers. These polymers were synthesized using batch reactors arranged in a 4 x 6 array, each reactor was magnetically stirred with temperature control, and had a volume of 350 microliters or 3 milliliters. In a typical procedure, first, the amine, the crosslinker and the solvent and possibly the base are added to the reactor by a robot with optional agitation. The reactor was then sealed and heated to the specified temperature for 15 hours. The reactor array was then removed and the crosslinked polymer mass transferred to a glass vial. After crushing, it was repeatedly washed with deionized water, and then freeze-dried. Table 3 shows the five polymer libraries and their corresponding s...

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Abstract

Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.

Description

[0001] cross reference [0002] This application is a continuation-in-part of: Serial No. 10 / 806,495 titled CROSSLINKED AMINE POLYMERS, filed March 22, 2004; serial number 10 / 701,385 titled POLYAMINE POLYMERS, filed November 3, 2003, and ANION-BINDING POLYMERS AND USES THEREOF, serial number 10 / 965,044, filed As of October 13, 2004, these applications are incorporated by reference in their entirety into this application. And claim priority to these applications according to 35 USC § 120. Background of the invention [0003] Ion-selective adsorbents have been used to treat electrolyte balance disorders caused by hyperphosphatemia, hyperoxaluria, hypercalcemia, and hyperkalemia in humans. Hyperphosphatemia occurs in patients with renal failure because the patient absorbs phosphate from the diet and their kidneys cannot effectively excrete phosphate ions. This results in very high serum phosphate concentrations and high calcium phosphate production. Although the etiology is n...

Claims

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Application Information

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IPC IPC(8): C08G73/00C08F26/06C11D1/00
CPCC11D1/00C08G73/00C08F26/06
Inventor 埃里克·康纳多米尼克·沙尔莫张汉廷弗洛朗斯·罗歇格里特·克莱尔内尔桑·霍艾·恩古延
Owner ILYPSA
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